PMID: 2120113Jul 1, 1990Paper

Molecular organization of the decapentaplegic gene in Drosophila melanogaster

Genes & Development
R D St JohnstonW M Gelbart

Abstract

The decapentaplegic (dpp) locus of Drosophila melanogaster is a greater than 55 kb genetic unit required for proper pattern formation during the embryonic and imaginal development of the organism. We have proposed that these morphogenetic functions result from the action of a secreted transforming growth factor-beta (TGF-beta)-related protein product encoded by dpp. In this paper we localize 60 mutations on the molecular map of dpp. The positions of these mutations cluster according to phenotypic class, identifying the locations of specific dpp functions. By Northern and cDNA analysis, we characterize five overlapping dpp transcripts. On the basis of the locations of the overlaps relative to a previously sequenced cDNA, it is likely that these transcripts all encode similar or identical polypeptides. We propose that the bulk of dpp DNA consists of extensive arrays of cis-regulatory information. The large (greater than 25-kb) 3' cis-regulatory region represents a novel feature of dpp gene organization

References

Aug 1, 1987·Genes & Development·E M Jorgensen, R L Garber
Sep 20, 1988·Journal of Molecular Biology·N H Brown, F C Kafatos
Jun 5, 1987·Science·T ManiatisJ A Fischer
Oct 1, 1985·Developmental Biology·S B Zusman, E F Wieschaus
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·W BenderM Peifer
Jan 1, 1985·Cold Spring Harbor Symposia on Quantitative Biology·D S HognessS L Helfand
Aug 25, 1983·Journal of Molecular Biology·P P Di NoceraI B Dawid
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·C Nüsslein-VolhardH Kluding
Sep 1, 1984·Wilhelm Roux's Archives of Developmental Biology·G JürgensH Kluding

❮ Previous
Next ❯

Citations

Jan 1, 1997·Developmental Genetics·F Chanut, U Heberlein
Jan 1, 1994·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P D Jackson, F M Hoffmann
Jun 1, 1992·Molecular Reproduction and Development·F M Hoffmann
Mar 1, 1997·Mammalian Genome : Official Journal of the International Mammalian Genome Society·S E GitelmanR Derynck
Mar 15, 2011·Development Genes and Evolution·Bethany R Wasik, Armin P Moczek
Mar 19, 2013·Insect Biochemistry and Molecular Biology·Shinya MatsudaOsamu Shimmi
Apr 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R W PadgettW M Gelbart
May 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Thüringer, M Bienz
Mar 17, 1999·The EMBO Journal·L Waltzer, M Bienz
Nov 15, 2001·The EMBO Journal·D St Johnston
Nov 9, 2007·Genome Research·Pär G EngströmBoris Lenhard
Sep 27, 2000·Evolution; International Journal of Organic Evolution·D L Stern
Mar 18, 2003·Molecular and Cellular Biology·Deborah L ThompsonRonald J Koenig
Oct 4, 2005·BMC Developmental Biology·Rebecca J DawberMarcel van den Heuvel
Jan 11, 2008·Development·Carlos Estella, Richard S Mann
Aug 24, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A Van den WijngaardW Olijve
Aug 4, 2001·Biochemical and Biophysical Research Communications·N Ghosh-ChoudhuryS E Harris
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·R J DiLeoneD M Kingsley
Jan 5, 2014·The Journal of Cell Biology·Zhao ZhangYun Zhao
Oct 13, 2015·Developmental Biology·Mélisande Richard, Michael Hoch
Nov 10, 2015·Nature·Takuya Akiyama, Matthew C Gibson
Jun 30, 2005·Genesis : the Journal of Genetics and Development·Brian G StultzDeborah A Hursh
Feb 28, 2003·Journal of Neurobiology·Yaël GrosjeanJean-François Ferveur
Apr 30, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Jose F De Celis
Sep 26, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Baharak ZahediNicholas Harden
Jun 15, 2011·Genesis : the Journal of Genetics and Development·Helena AraujoRodrigo Nunes da Fonseca
Dec 17, 2014·Development, Growth & Differentiation·Yue XiongYun Zhao
Jan 5, 2010·Developmental Biology·Julia Zeitlinger, Alexander Stark
Jan 24, 1992·Cell·W McGinnis, R Krumlauf
Jul 12, 1991·Cell·D St JohnstonC Nüsslein-Volhard

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.