PMID: 2496753Feb 7, 1989Paper

Molecular packing of high-density and low-density lipoprotein surface lipids and apolipoprotein A-I binding

Biochemistry
J A IbdahM C Phillips

Abstract

The surface pressure (pi)-molecular area (A) isotherms for monolayers of human high-density lipoprotein (HDL3) and low-density lipoprotein (LDL) phospholipids and of mixed monolayers of these phospholipids with cholesterol spread at the air-water interface were used to deduce the likely molecular packing at the surfaces of HDL3 and LDL particles. LDL phospholipids form more condensed monolayers than HDL3 phospholipids; for example, the molecular areas of LDL and HDL3 phospholipids at pi = 10 dyn/cm are 88 and 75 A2/molecule, respectively. The closer packing in the LDL phospholipids monolayer can be attributed to the higher contents of saturated phosphatidylcholines and sphingomyelin relative to HDL3. Cholesterol condenses both HDL3 and LDL phospholipid monolayers but has a greater condensing effect on the LDL phospholipid monolayer. The pi-A isotherms for mixed monolayer of HDL3 phospholipid/cholesterol and LDL phospholipid/cholesterol at stoichiometries similar to those at the surfaces of lipoprotein particles suggest that the monolayer at the surface of the LDL particle is significantly more condensed than that at the surface of the HDL3 particle. The closer lateral packing in LDL is due to at least three factors: (1) the dif...Continue Reading

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Citations

Sep 28, 1992·Advances in Colloid and Interface Science·D H Small, M Phillips
Aug 22, 1989·Biochimica Et Biophysica Acta·J A IbdahM C Phillips
Feb 1, 1990·Chemistry and Physics of Lipids·M Vauhkonen, P Somerharju
Mar 31, 1994·Chemistry and Physics of Lipids·E Schnitzer, D Lichtenberg
Jul 11, 2003·Biomaterials·Béatrice HeurtaultJean-Pierre Benoit
Aug 24, 1999·Biophysical Chemistry·M M GhannamW A Khalil
Mar 15, 2011·Nature Structural & Molecular Biology·Rong HuangW Sean Davidson
Oct 26, 2000·Current Opinion in Lipidology·E Hurt-CamejoP Sartipy
Apr 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Libo WangDonald M Small
Apr 23, 2011·Journal of Molecular Biology·Lionel ChièzeVéronique Vié
Feb 23, 2012·Scientific Reports·Monireh DashtiFarhad Rezaee
Oct 30, 2010·Journal of Molecular Biology·Yuhang Liu, David Atkinson
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May 4, 2002·Annual Review of Biophysics and Biomolecular Structure·Robert J Cushley, Mark Okon
Jan 22, 1991·Biochemistry·J Y Letizia, M C Phillips
Apr 11, 2013·International Journal of Molecular Sciences·Roberto Martínez-BeamonteJesús Osada
May 31, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nathalie NiyonzimaTerje Espevik

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