Molecular pathogenesis and targeted therapeutics in Ewing sarcoma/primitive neuroectodermal tumours.

Clinical Sarcoma Research
Fergal C Kelleher, David M Thomas

Abstract

Ewing sarcoma/PNET is managed with treatment paradigms involving combinations of chemotherapy, surgery, and sometimes radiation. Although the 5-year survival rate of non-metastatic disease approaches 70%, those cases that are metastatic and those that recur have 5-year survival rates of less than 20%. Molecularly targeted treatments offer the potential to further improve treatment outcomes. A PUBMED search was performed from 1997 to 2011. Published literature that included the topic of the Ewing sarcoma/PNET was also referenced. Insulin-like growth factor-1 receptor (IGF-1R) antagonists have demonstrated modest single agent efficacy in phase I/II clinical trials in Ewing sarcoma/PNET, but have a strong preclinical rationale. Based on in vitro and animal data, treatment using antisense RNA and cDNA oligonucleotides directed at silencing the EWS-FLI chimera that occurs in most Ewing sarcoma/PNET may have potential therapeutic importance. However drug delivery and degradation problems may limit this therapeutic approach. Protein-protein interactions can be targeted by inhibition of RNA helicase A, which binds to EWS/FLI as part of the transcriptional complex. Tumour necrosis factor related apoptosis inducing ligand induction using...Continue Reading

References

Apr 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A ZoubekH Kovar
Jan 10, 1998·The Journal of Biological Chemistry·J A ToretskyL J Helman
Dec 17, 1997·Nature Genetics·W A MayC T Denny
Jan 27, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A StaalJ P Van Leeuwen
Apr 29, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·E de AlavaM Ladanyi
Mar 7, 2000·The American Journal of Pathology·E de AlavaM Ladanyi
Aug 30, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S J CotterillA W Craft
May 18, 2001·British Journal of Cancer·S A BoernerK C Bible
Feb 1, 2003·The Journal of Biological Chemistry·Fumihiko NakataniYukihide Iwamoto
Mar 26, 2003·Medical and Pediatric Oncology·Carlos Rodriguez-GalindoAlberto S Pappo
Aug 21, 2003·Breast Cancer Research : BCR·Manuel Oscar Gomez Cuadra
Dec 4, 2003·International Journal of Cancer. Journal International Du Cancer·Stefania BeniniKatia Scotlandi
Mar 27, 2004·The New England Journal of Medicine·Stefan S BielackGabriele Köhler
May 28, 2004·Expert Opinion on Pharmacotherapy·Carlos Rodriguez-Galindo
Nov 20, 2004·Cancer Gene Therapy·Lidong Zhang, Bingliang Fang
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neyssa Marina, Paul A Meyers
Mar 23, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa M BarkerDouglas S Hawkins
Apr 9, 2005·International Journal of Cancer. Journal International Du Cancer·Xu LiYukihide Iwamoto
Apr 26, 2005·International Journal of Cancer. Journal International Du Cancer·Riku SakimuraYukihide Iwamoto
Dec 6, 2005·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Katia ScotlandiPiero Picci
Jan 18, 2006·Pediatric Blood & Cancer·Andrea HunoldHerbert Jürgens
Mar 30, 2006·International Journal of Cancer. Journal International Du Cancer·Stefania BeniniKatia Scotlandi
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ana S MartinsEnrique de Alava
Nov 24, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Silvia Mateo-LozanoVicente Notario
Feb 15, 2007·Pathology, Research and Practice·Ingu DoYong-Koo Park
Apr 26, 2007·The American Journal of Pathology·Frank BalikoBenjamin A Alman
May 8, 2007·Cancer Cell·Franck TirodeOlivier Delattre
Jan 11, 2008·The New England Journal of Medicine·John J BisslerDavid N Franz
Jan 11, 2008·The New England Journal of Medicine·Elahna Paul, Elizabeth Thiele

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Citations

Aug 21, 2013·Surgical Neurology International·Atef Ben NsirNejib Hattab
Jan 29, 2014·Cancer Chemotherapy and Pharmacology·Atif A AhmedLars Wagner
Aug 12, 2014·Advanced Drug Delivery Reviews·Salah-Eddine Lamhamedi-CherradiJoseph A Ludwig
Jan 25, 2013·ISRN Oncology·Keir A RossJohn G Kennedy
Feb 26, 2014·World Journal of Stem Cells·Mojdeh Safari, Alireza Khoshnevisan
Sep 6, 2017·Pediatric Blood & Cancer·Sun ChooJing Yang
Sep 18, 2013·Molecular and Cellular Biology·Savita SankarStephen L Lessnick
Dec 16, 2017·JBJS Case Connector·Julia BedardAmalia de Comas
Dec 30, 2020·International Journal of Radiation Oncology, Biology, Physics·Mei Yun LinJason A Horton
Feb 25, 2021·Journal of Pediatric Hematology/oncology·Adam S HoweBarry A Kogan

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Methods Mentioned

BETA
xenograft
antisense oligonucleotide
xenografts
acetylation

Clinical Trials Mentioned

NCT01154452
NCT01154816
NCT00831844
NCT00678223
NCT00678769
NCT01287104
NCT00918320

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