Molecular pathogenesis of follicular cell derived thyroid cancers

International Journal of Surgery
Rajeev ParameswaranGregory Paul Sadler

Abstract

Thyroid cancers are the most common endocrine malignancy. Radiation exposure, family history of thyroid cancer and some inherited conditions are the most important predisposing factors for the development of thyroid cancer. Three mitogenic signalling pathways have been described in the thyroid cell, which are influenced by various stimulatory and inhibitory hormones, growth factors and neurotransmitters. Various proto-oncogenes and oncogenes like ras, braf, trk, met and RET also play a role in the signal transduction systems. Two theories have been described in thyroid cancer pathogenesis, the foetal cell carcinogenesis theory and the more common, multistep carcinogenesis theory. The multistep carcinogenesis theory is now the accepted model in many human cancers, including thyroid cancer. The early events of tumour formation are the consequence of activation of either various growth factors or the proto-oncogenes like ras, met or ret. This results in the formation of differentiated thyroid cancers like the papillary, follicular or Hurthle cell cancers. The later stages of tumour formation involve further activation of proto-oncogenes and loss or inactivation of tumour suppressor genes like p53. Based on this theory, follicular ...Continue Reading

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Citations

Jul 20, 2011·Thyroid : Official Journal of the American Thyroid Association·Briseis Aschebrook-KilfoyMary H Ward
Jul 11, 2012·Experimental Diabetes Research·Shyang-Rong ShihChin-Hsiao Tseng
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Mar 25, 2021·Environmental Toxicology·Mariana Pires TeixeiraLuciana Souza de Paiva

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