Molecular pathogenesis of renal cell carcinoma: Impact of the anti-tumor miR-29 family on gene regulation.

International Journal of Urology : Official Journal of the Japanese Urological Association
Yasutaka YamadaNaohiko Seki

Abstract

To identify key oncogenes and proteins that are controlled by the microRNA miR-29 family (miR-29a, miR-29b and miR-29c) in renal cell carcinoma pathogenesis. Genome-wide gene expression and in silico database analyses were carried out. The Cancer Genome Atlas database was used to investigate the clinical significance of gene expression data in renal cell carcinoma patients. Loss-of-function assays were applied to investigate the function of target genes. We identified 47 possible target genes that might be regulated by the miR-29 family in renal cell carcinoma cells. Among the targets of the miR-29 family, high expression of 10 genes (ADAMTS14, TRIB13, SERPINH1, FCGR1B, COL1A1, LAIR2, WISP2, TREM1, TNKS1BP1 and GBP2) significantly predicted poor patient prognosis (P < 0.001). SERPINH1 was directly regulated by the miR-29 family, and its overexpression was detected in renal cell carcinoma surgical specimens and tyrosine kinase inhibitor failure autopsy specimens. High expression of SERPINH1 was significantly associated with tumor stage, pathological grade and poor prognosis (P < 0.0001). Knockdown assays showed that its expression enhanced cancer cell migration and invasive abilities. Genes regulated by the anti-tumor miR-29 fam...Continue Reading

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Citations

Mar 1, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Takayuki AraiNaohiko Seki
Jan 14, 2020·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiaoqiu YangZhiwu Han
Jan 25, 2020·Cancer Science·Yasutaka YamadaNaohiko Seki
Jan 28, 2021·Cancers·Tamsin Joy RobbCherie Blenkiron
Apr 17, 2021·BioMed Research International·Siwei BiJun Gu

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