Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

Clinical Microbiology Reviews
Gunnar N Schroeder, Hubert Hilbi

Abstract

Shigella spp. are gram-negative pathogenic bacteria that evolved from harmless enterobacterial relatives and may cause devastating diarrhea upon ingestion. Research performed over the last 25 years revealed that a type III secretion system (T3SS) encoded on a large plasmid is a key virulence factor of Shigella flexneri. The T3SS determines the interactions of S. flexneri with intestinal cells by consecutively translocating two sets of effector proteins into the target cells. Thus, S. flexneri controls invasion into EC, intra- and intercellular spread, macrophage cell death, as well as host inflammatory responses. Some of the translocated effector proteins show novel biochemical activities by which they intercept host cell signal transduction pathways. An understanding of the molecular mechanisms underlying Shigella pathogenesis will foster the development of a safe and efficient vaccine, which, in parallel with improved hygiene, should curb infections by this widespread pathogen.

References

Apr 3, 1992·Science·D P CerrettiL A Cannizzaro
Jul 9, 1992·Nature·A ZychlinskyP J Sansonetti
Mar 1, 1991·Reviews of Infectious Diseases·A A LindbergA Weintraub
Oct 1, 1991·Applied and Environmental Microbiology·H ItoN Kato
May 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M L BernardiniP J Sansonetti
Jun 1, 1989·The Journal of Infectious Diseases·H L DuPontS B Formal
Jul 1, 1987·Microbial Pathogenesis·P J Sansonetti, J Mounier
Jul 1, 1985·Infection and Immunity·A T MaurelliP J Sansonetti
Mar 1, 1982·Infection and Immunity·P J SansonettiS B Formal
Sep 1, 1983·Journal of General Microbiology·H OchmanR K Selander
Sep 1, 1982·Journal of General Microbiology·C E Dodd, D Jones
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·M B Goldberg, J A Theriot
Aug 1, 1995·The Journal of Clinical Investigation·P J SansonettiM Huerre
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·M WataraiC Sasakawa
Feb 1, 1994·The Journal of Clinical Investigation·J J PerdomoP J Sansonetti
Oct 1, 1994·The Journal of Experimental Medicine·O J PerdomoP J Sansonetti
Jul 28, 1994·Nature·K P WilsonS A Raybuck

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Citations

Jun 5, 2013·Biologicals : Journal of the International Association of Biological Standardization·Mahdi HesarakiReza Ranjbar
Mar 23, 2011·Immunology and Cell Biology·Jet Phey Lim, Paul A Gleeson
Feb 20, 2013·Nature Reviews. Gastroenterology & Hepatology·Eileen M BarryMyron M Levine
Apr 17, 2009·Nature Reviews. Microbiology·Katrina RayChristoph M Tang
Dec 8, 2009·Nature Reviews. Microbiology·Matthew A Croxen, B Brett Finlay
Apr 28, 2009·Molecular BioSystems·Yu WangRoberto N De Guzman
Jan 12, 2011·Proceedings of the National Academy of Sciences of the United States of America·Karen AkopyanMaria Fallman
Mar 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Takashi FujiiKeiichi Namba
Aug 16, 2011·The Journal of Biological Chemistry·Tara L ArchuletaBenjamin W Spiller
Apr 10, 2010·Microbiology and Immunology·Anetta HartlovaJiri Stulik
Nov 4, 2009·Infection and Immunity·Ryan T RanalloMalabi M Venkatesan
Oct 10, 2012·Infection and Immunity·Kimberly A Bliven, Anthony T Maurelli
Dec 2, 2009·Infection and Immunity·Tao Dong, Herb E Schellhorn
Jul 22, 2008·Journal of Bacteriology·Nicole C AmmermanAbdu F Azad
Jul 17, 2010·BMC Structural Biology·Michael L BartaBrian V Geisbrecht
Mar 10, 2010·Future Microbiology·Vernon L Tesh
Apr 16, 2013·Journal of Immunological Methods·Robert W KaminskiEdwin V Oaks
Mar 13, 2014·Trends in Microbiology·Wilmara Salgado-PabónArmelle Phalipon

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