Molecular Pathology and Personalized Medicine: The Dawn of a New Era in Companion Diagnostics-Practical Considerations about Companion Diagnostics for Non-Small-Cell-Lung-Cancer

Journal of Personalized Medicine
Till PlönesVerena Schildgen

Abstract

Companion diagnostics (CDx) have become a major tool in molecular pathology and assist in therapy decisions in an increasing number of various cancers. Particularly, the developments in lung cancer have been most impressing in the last decade and consequently lung cancer mutation testing and molecular profiling has become a major business of diagnostic laboratories. However, it has become difficult to decide which biomarkers are currently relevant for therapy decisions, as many of the new biomarkers are not yet approved as therapy targets, remain in the status of clinical studies, or still have not left the experimental phase. The current review is focussed on those markers that do have current therapy implications, practical implications arising from the respective companion diagnostics, and thus is focused on daily practice.

References

Jan 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J C RuckdeschelS Vogl
Jul 31, 2004·Science·Raffaella SordellaJeffrey Settleman
Aug 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·William PaoHarold Varmus
May 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eunice L KwakDaniel A Haber
Oct 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daphne W BellDaniel A Haber
Dec 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·James BeanWilliam Pao
Mar 31, 1949·The New England Journal of Medicine·R H OVERHOLT, I C SCHMIDT
May 7, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistThomas J Lynch
Jul 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daphne W BellDaniel A Haber
Sep 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gregory J RielyMarc Ladanyi
Oct 4, 2008·The Journal of Molecular Diagnostics : JMD·Gregory J Riely, Marc Ladanyi
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiHiroyuki Mano
Nov 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel B CostaSusumu Kobayashi
Nov 19, 2008·Seminars in Diagnostic Pathology·Joaquin GarciaMarc Ladanyi
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Scott J RodigLucian R Chirieac
Dec 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lee M Ellis, Daniel J Hicklin
Jan 16, 2010·The American Journal of Pathology·Hiroyuki Mano, Kengo Takeuchi
Jan 20, 2011·Neoplasia : an International Journal for Oncology Research·Yongjun LiLin Pei
Mar 15, 2011·Cancer Cytopathology·Shahreen BillahMing Guo
Apr 13, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sandra P D'AngeloMark G Kris
Apr 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ryohei KatayamaAlice T Shaw
Jun 24, 2011·Bioinformatics·Jason R GrantPaul Stothard
Dec 14, 2011·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Pierre-Alexandre JustHélène Blons
Apr 13, 2012·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nobuhiro KanajiTakuya Matsunaga
Apr 21, 2012·Human Mutation·Junfeng XiaZhongming Zhao
Jun 19, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Roland PenzelArne Warth
Aug 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johannes M HeuckmannRoman K Thomas
Feb 2, 2013·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Verena SchildgenMichael Brockmann
Feb 13, 2013·Cancer·Verena Schildgen, Oliver Schildgen
Mar 28, 2013·Cancer Discovery·Alexander DrilonNaiyer Rizvi
Apr 19, 2013·Journal of the National Cancer Institute·Chee Khoon LeeJames Chih-Hsin Yang
Apr 30, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Ka-Fai ToTony S K Mok
May 15, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Maximilian V LaffertMichael Hummel

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Citations

Oct 25, 2017·Pharmacogenomics·Kathi L HuddlestonSusanne B Haga
Dec 11, 2019·The Pharmacogenomics Journal·Arun RadhakrishnanNikhitha K Shanmukhan
Dec 5, 2018·Essays in Biochemistry·Maria JacksonJoanna B Wilson
Jan 7, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jennifer L Hunt
Dec 17, 2020·Journal of Personalized Medicine·Ines Viktoria StelzerJudit Simon
Aug 18, 2021·Frontiers in Immunology·Hongen YinUNKNOWN NIDCD/NIDCR Genomics and Computational Biology Core

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Methods Mentioned

BETA
array technology
PCR
biopsies
transfection
PCRs

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