Molecular pathways: rodent parvoviruses--mechanisms of oncolysis and prospects for clinical cancer treatment

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Jürg P F NüeschJean Rommelaere

Abstract

Rodent parvoviruses (PV) are recognized for their intrinsic oncotropism and oncolytic activity, which contribute to their natural oncosuppressive effects. Although PV uptake occurs in most host cells, some of the subsequent steps leading to expression and amplification of the viral genome and production of progeny particles are upregulated in malignantly transformed cells. By usurping cellular processes such as DNA replication, DNA damage response, and gene expression, and/or by interfering with cellular signaling cascades involved in cytoskeleton dynamics, vesicular integrity, cell survival, and death, PVs can induce cytostasis and cytotoxicity. Although productive PV infections normally culminate in cytolysis, virus spread to neighboring cells and secondary rounds of infection, even abortive infection or the sole expression of the PV nonstructural protein NS1, is sufficient to cause significant tumor cell death, either directly or indirectly (through activation of host immune responses). This review highlights the molecular pathways involved in tumor cell targeting by PVs and in PV-induced cell death. It concludes with a discussion of the relevance of these pathways to the application of PVs in cancer therapy, linking basic k...Continue Reading

References

Dec 9, 1997·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C Van PachterbekeJ Rommelaere
May 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·T BashirK Willwand
Oct 17, 2001·Journal of Virology·A Op De BeeckP Caillet-Fauquet
Nov 14, 2002·Annual Review of Genetics·Kara A NybergTed A Weinert
Aug 17, 2004·Journal of Virology·Refael ItahClaytus Davis
Apr 28, 2006·Journal of Virology·Jürg P F Nüesch, Jean Rommelaere
Jul 20, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jürg P F Nüesch, Jean Rommelaere
Sep 4, 2007·Advances in Virus Research·Susan F Cotmore, Peter Tattersall
Sep 6, 2007·Cancer Biology & Therapy·Sara Abu-GhanemEtta Livneh
Mar 25, 2008·International Journal of Cancer. Journal International Du Cancer·Zahari RaykovJean Rommelaere
Jul 9, 2008·World Journal of Gastroenterology : WJG·Maike SiebenMarkus Moehler
Aug 16, 2008·PLoS Pathogens·Séverine BärJürg P F Nüesch
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Assia L AngelovaZahari Raykov
Apr 16, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Assia L AngelovaZahari Raykov
Oct 27, 2009·International Journal of Cancer. Journal International Du Cancer·Sebastian DempeChristiane Dinsart
Jan 21, 2010·International Journal of Cancer. Journal International Du Cancer·Jeannine LacroixOlaf Witt
Mar 10, 2010·Cytokine & Growth Factor Reviews·Jean RommelaereZahari Raykov
Mar 13, 2010·Journal of Biomedicine & Biotechnology·Karsten GeletnekyJoerg R Schlehofer
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Rauf BhatJean Rommelaere
Nov 4, 2010·Nucleic Acids Research·Damian SzklarczykChristian von Mering

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Citations

Jul 13, 2012·Journal of Virology·Nazim El-AndaloussiAntonio Marchini
Dec 3, 2013·Nature Reviews. Microbiology·Tanner S Miest, Roberto Cattaneo
Nov 26, 2015·Human Gene Therapy·Georges VassauxPierre Cordelier
Dec 15, 2015·Journal of Virological Methods·Barbara LeuchsJean Rommelaere
Sep 1, 2014·Virology·Pierre O Garcin, Nelly Panté
Feb 9, 2016·Expert Opinion on Biological Therapy·Cherif Akladios, Marc Aprahamian
Apr 5, 2015·Current Opinion in Virology·Karsten GeletnekyJean Rommelaere
Jan 30, 2015·Virology Journal·Antonio MarchiniJean Rommelaere
Mar 15, 2015·Virology·Pierre O GarcinNelly Panté
Nov 20, 2014·Cellular and Molecular Life Sciences : CMLS·Shishir Kumar GuptaA K Tiwari
Nov 3, 2014·Annual Review of Virology·Susan F Cotmore, Peter Tattersall
Oct 27, 2017·Viruses·Carlos RosJosé M Almendral
Sep 6, 2017·Human Gene Therapy·Guy UngerechtsDirk M Nettelbeck
May 8, 2019·Viruses·Assia Angelova, Jean Rommelaere
Jul 10, 2019·Annual Review of Virology·Maria Söderlund-Venermo
Jul 1, 2020·Annual Review of Virology·Anna HartleyAntonio Marchini
Aug 24, 2019·Frontiers in Immunology·Antonio MarchiniJean Rommelaere
Jun 21, 2019·Viruses·Clemens Bretscher, Antonio Marchini
Jan 1, 2014·Molecular and Cellular Therapies·Magid H Amer
Sep 29, 2017·Frontiers in Oncology·Sachin R JhawarAndrew Zloza
Feb 10, 2021·Cancers·Eftychia StavrakakiMartine L M Lamfers
Dec 23, 2020·Biomedicines·Ivan Y FilinAlbert A Rizvanov
Apr 25, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Dominik WitzigmannJörg Huwyler
Apr 9, 2021·Molecular Therapy : the Journal of the American Society of Gene Therapy·Julia Fakhiri, Dirk Grimm
Jun 24, 2021·Nature Communications·Amit KulkarniAntonio Marchini
Aug 25, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jacek HajdaGuy Ungerechts

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