Molecular Patterns Discriminate Accommodation and Subclinical Antibody-mediated Rejection in Kidney Transplantation

Transplantation
Petra HrubaO Viklicky

Abstract

Accommodation in ABO-incompatible (ABOi) transplantation and subclinical antibody-mediated rejection in HLA-incompatible (HLAi) transplantation share several morphological similarities. Because the clinical long-term outcomes differ, we hypothesized different molecular processes involved in ABOi transplantation and subclinical antibody-mediated rejection. Using Illumina Human HT-12 v4 Expression BeadChips, the whole transcriptome was evaluated based on 3-month protocol C4d+ biopsies in otherwise stable ABOi and HLAi kidney grafts, as well as in C4d-negative HLA-compatible grafts exhibiting normal histological findings. Top differently regulated genes were further validated using real-time quantitative polymerase chain reaction in another patient cohort and complement regulatory proteins by immunohistochemistry. In the case of genes involved in immune response-related biological processes, ABOi and HLAi cohorts had similar transcriptomic profiles to C4d-negative controls. The majority of deregulated genes in the ABOi and HLAi groups consisted of metallothioneins and epithelial transporter genes. Increased expression of epithelial transporters (SLC4A1, SLC4A9, SLC17A3, SLC12A3, and SLC30A2) and class 1 metallothioneins (MT1F, MT1...Continue Reading

References

Dec 26, 2001·Nucleic Acids Research·Ron EdgarAlex E Lash
Jul 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Walter D ParkMark D Stegall
Jan 8, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Gunnar TydénIngela Fehrman
Apr 26, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·G EineckeP F Halloran
Feb 6, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Peter T JindraElaine F Reed
Aug 8, 2008·Current Opinion in Organ Transplantation·Raymond J Lynch, Jeffrey L Platt
Jan 17, 2009·Kidney International·Ichiro KojimaMasaomi Nangaku
Sep 25, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·X Zhang, E F Reed
Dec 17, 2009·Biochemical and Biophysical Research Communications·Kenta IwasakiTakaaki Kobayashi
Sep 3, 2010·The Journal of Biological Chemistry·Promsuk JutabhaHiroyuki Sakurai
Dec 17, 2010·The British Journal of Radiology·K IwasakiY Iwamoto
Jun 15, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·N V RekersM Eikmans
Jan 10, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A DjamaliM Samaniego
Nov 12, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M OkumiK Tanabe
Feb 26, 2016·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Johannes LeiererGert Mayer
Aug 27, 2017·Seminars in Immunopathology·Justin KillickAnne L Astier
Nov 23, 2017·Frontiers in Medicine·Silke RoedderMinnie M Sarwal
Dec 16, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M HaasM Mengel
Jul 22, 2018·Transplantation·Candice RoufosseJan U Becker

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Citations

Aug 6, 2020·International Journal of Molecular Sciences·Marco QuagliaVincenzo Cantaluppi
Jul 28, 2020·Clinical Transplantation·Menger CenJianghua Chen
Dec 14, 2019·Current Opinion in Organ Transplantation·Ondrej ViklickyPetra Hruba

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