Abstract
Most studies of the immune responses in allergic rhinitis have focused on IgE antibodies to mixtures of allergenic proteins. Based on our previous studies of the major mountain cedar allergen Jun a 1, we sought to describe a broader assessment of the humoral immune responses to a single, dominant allergen, in three groups of allergic subjects, all of whom had similarly exposures to the whole cedar pollen. The major outcomes of this study was that, with the onset of allergic rhinitis symptoms, and after treatment with immunotherapy, serum IgE and IgG (but not IgA) antibodies to Jun a 1 increased. Interestingly, both IgE and IgG4 antibodies to the Jun a 1 allergen were strongly focused on its conformation epitopes. These IgG antibodies to conformationalstructures may be a useful marker of the therapeutic response to immunotherapy.
References
Oct 1, 1992·Acta Paediatrica Japonica; Overseas Edition·T Midoro-HoriutiY Seino
Sep 14, 1999·The Journal of Allergy and Clinical Immunology·T Midoro-HoriutiE G Brooks
Feb 5, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T Midoro-HoriutiE G Brooks
Jun 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·O MirzaM Gajhede
Sep 2, 2000·Biophysical Journal·K V SomanC H Schein
Jun 5, 2003·Acta Crystallographica. Section D, Biological Crystallography·Dequin LiuEdmund W Czerwinski
Oct 18, 2003·Molecular Immunology·Terumi Midoro-HoriutiRandall M Goldblum
Nov 13, 2004·The Journal of Biological Chemistry·Edmund W CzerwinskiRandall M Goldblum
Jun 21, 2005·Microbiology and Immunology·Tomoaki YoshidaTakashi Yokochi
Jan 21, 2006·Molecular Immunology·Shikha VarshneyTerumi Midoro-Horiuti
Mar 6, 2007·The Journal of Allergy and Clinical Immunology·Carmen RondónMiguel Blanca
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sivaraman PadavattanZora Markovic-Housley
May 7, 2009·Current Opinion in Otolaryngology & Head and Neck Surgery·Sarah K WiseRodney J Schlosser
May 9, 2009·Journal of Agricultural and Food Chemistry·Rieko AokiAkio Kato
Apr 1, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Anna GierasRudolf Valenta
Apr 21, 2012·The Journal of Allergy and Clinical Immunology·Carmen RondónMiguel Blanca
Sep 24, 2013·Allergy·B SubbarayalB Bohle
Nov 5, 2013·The Journal of Allergy and Clinical Immunology·Margarete Focke-TejklRudolf Valenta
Jul 1, 2014·The Journal of Allergy and Clinical Immunology·Randall M GoldblumTerumi Midoro-Horiuti
Aug 16, 2014·Allergy·S C DevanaboyinaW Keller
May 16, 2015·PloS One·Ulrike PichlerFátima Ferreira
May 14, 2016·Molecular Immunology·Randall M GoldblumTerumi Midoro-Horiuti
May 28, 2016·The Journal of Biological Chemistry·Lesa R OffermannMaksymilian Chruszcz
Sep 30, 2017·Allergy·I PablosG Gadermaier