Molecular Phenotyping Small (Asian) versus Large (Western) Plaque Psoriasis Shows Common Activation of IL-17 Pathway Genes but Different Regulatory Gene Sets

The Journal of Investigative Dermatology
Jaehwan KimJames G Krueger

Abstract

Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian small and intermediate plaque psoriasis as psoriasis subtypes and compared their molecular signatures with the classic subtype of Western large plaque psoriasis. Two different characteristics of psoriatic spreading-vertical growth and radial expansion-were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared with Western large plaque psoriasis, Asian small plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated proinflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated proinflammatory cytokines were lower in Western large plaque psoriasis, whereas T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western large plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the di...Continue Reading

Associated Clinical Trials

Apr 27, 2017·James G. Krueger, MD, PhD

Citations

Nov 23, 2016·Current Opinion in Rheumatology·Helen Alexander, Frank O Nestle
Sep 1, 2018·The Journal of Dermatology·Megumi KishimotoMamitaro Ohtsuki
Jul 23, 2020·The Journal of Dermatological Treatment·Yanfei Zhang
Jul 5, 2017·Internal Medicine·Masutaka FurueTakafumi Kadono
Jan 4, 2017·Mediators of Inflammation·Priscilla Stela Santana de OliveiraMaira Galdino da Rocha Pitta
Jul 10, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·J W LeeM G Lee
Oct 1, 2016·Annual Review of Medicine·Jaehwan Kim, James G Krueger
May 26, 2017·The British Journal of Dermatology·J DouX Zhang
Aug 8, 2021·Journal of Clinical Medicine·Masaru Honma, Hiroyoshi Nozaki
Dec 11, 2021·Experimental Dermatology·Touraj Khosravi-HafshejaniJan P Dutz

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Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT01920906

Software Mentioned

Gene Set Variation Analysis ( GSVA )

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