PMID: 7929615Jan 1, 1994Paper

Molecular physiology of amylin

Journal of Cellular Biochemistry
R A PittnerT J Rink

Abstract

Amylin is a 37-amino acid peptide first isolated, purified, and characterized from the amyloid deposits in the pancrease of type 2 diabetics. It is synthesized and secreted primarily from pancreatic beta cells along with insulin. The ability of amylin to potently reduce insulin-stimulated incorporation of glucose into glycogen in skeletal muscle requires both an intact 2Cys-7Cys disulfide bond and a COOH-terminal amide. Amylin has structural and functional relationships to two other messenger proteins, calcitonin and CGRP. Amylin has relatively potent calcitonin-like activity on bone metabolism and weaker CGRP-like activity on the vasculature. CGRP is a slightly weaker agonist than amylin for metabolic responses. Although rat calcitonins are weak, teleost fish calcitonins are very potent agonists for amylin's metabolic effects. This group of peptides appears to act on a family of related G protein-coupled receptors; several variant calcitonin receptors have recently been cloned and expressed. These receptors appear to be coupled to adenylyl cyclase in many instances; recent evidence supports the view that amylin's effects on skeletal muscle occur, at least in large part, through activation of the cAMP pathway.

References

Apr 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·J C LawrenceD E James
Nov 1, 1992·The Journal of Clinical Investigation·A H GornS R Goldring
May 9, 1992·Lancet·J E KodaL G Linarelli
Nov 20, 1992·Brain Research·P M Sexton, J M Hilton
Jul 31, 1992·Biochemical and Biophysical Research Communications·K ShiomiS Matsukura
Apr 1, 1992·Metabolism: Clinical and Experimental·S NishimuraK Nanjo
Jan 1, 1992·Journal of Diabetes and Its Complications·J S Cameron
Jun 14, 1991·Biochemical and Biophysical Research Communications·G C ZhuA R Saltiel
Dec 1, 1991·Acta Physiologica Scandinavica·E J Henriksen, J O Holloszy
Jan 31, 1991·Biochemical and Biophysical Research Communications·R O DeemsD A Young
Jun 15, 1991·The Biochemical Journal·A M Gómez-FoixJ J Guinovart
Jan 1, 1990·Critical Reviews in Clinical Laboratory Sciences·M ZaidiL H Breimer
Jan 1, 1991·Hypertension·T YamaguchiA G Scicli
Feb 28, 1991·Biochemical and Biophysical Research Communications·J R StrahlerS M Hanash
Jun 28, 1991·Biochemical and Biophysical Research Communications·C L BroderickG Gold

❮ Previous
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Citations

Aug 6, 1997·European Journal of Pharmacology·G ClementiM Amico-Roxas
Jan 1, 1997·Peptides·I VillaF Guidobono
Feb 1, 1997·British Journal of Pharmacology·F GuidobonoC Netti
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Zaida AlipioYupo Ma
Jul 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Katrina M MirandaDavid A Wink
Jul 1, 1995·British Journal of Pharmacology·K BeaumontT J Rink
Jul 30, 2005·Neuromolecular Medicine·Bronwen MartinStuart Maudsley
Jan 21, 2012·The Review of Diabetic Studies : RDS·Hannah C GreenwoodKevin G Murphy
Nov 19, 2009·Drug Design, Development and Therapy·Gina RyanLynette Jobe
Jan 1, 2014·Journal of Clinical Medicine·Dante J MerlinoScott A Waldman
Apr 30, 2013·Expert Opinion on Drug Discovery·Gilbert W KimScott A Waldman
Oct 30, 2012·Molecular Aspects of Medicine·Francheska Colon-GonzalezScott A Waldman
Jun 21, 2012·The International Journal of Biochemistry & Cell Biology·Gaetano InvernizziSalvador Ventura
Mar 1, 2010·The EPMA Journal·Cristina M SenaRaquel Seiça
May 26, 2009·Peptides·Giuseppina CantarellaRenato Bernardini
Dec 2, 2004·Peptides·Tatjana Abaffy, Garth J S Cooper
Dec 7, 2005·Clinical Therapeutics·Gina J RyanRhonda Martin
Oct 12, 2002·Obesity Research·Tarek K RedaF Xavier Pi-Sunyer
Jul 1, 1997·Journal of Structural Biology·D J MüllerA Engel
May 11, 2018·Chemical Communications : Chem Comm·Diana C Rodriguez CamargoBernd Reif
May 8, 2002·Diabetes/metabolism Research and Reviews·Kieren J MatherAlain D Baron
Nov 24, 2018·Diabetes/metabolism Research and Reviews·Evangelia KalaitzoglouKathryn M Thrailkill
Oct 1, 1996·Annals of the Rheumatic Diseases·S Patel
Aug 10, 2000·Drugs·J M Chehade, A D Mooradian
Sep 15, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Christine MackDavid Parkes
Oct 17, 2009·American Journal of Therapeutics·Zafar H Israili
Feb 8, 2011·Expert Review of Endocrinology & Metabolism·Michael A ValentinoScott A Waldman
Dec 5, 2012·Acta Cirúrgica Brasileira·Ester Verônica BrustolinCamila Ercolin Ramos
Jul 26, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Andreas StengelYvette Taché
Dec 18, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Luciana ScottiMarcus Tullius Scotti
May 19, 2005·American Journal of Physiology. Endocrinology and Metabolism·Rebecca L HullSteven E Kahn
Mar 13, 2003·Canadian Journal of Dietetic Practice and Research : a Publication of Dietitians of Canada = Revue Canadienne De La Pratique Et De La Recherche En Diététique : Une Publication Des Diététistes Du Canada·Debbie L Maclellan, Shawna Berenbaum
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mayara C F GewehrEmer S Ferro
Mar 20, 2001·American Journal of Physiology. Endocrinology and Metabolism·J M YeE W Kraegen
Jun 15, 2011·Expert Review of Clinical Pharmacology·Gilbert W KimScott A Waldman

❮ Previous
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