Molecular piracy of Kaposi's sarcoma associated herpesvirus

Cytokine & Growth Factor Reviews
J ChoiJ U Jung

Abstract

Kaposi's Sarcoma associated Herpesvirus (KSHV) is the most recently discovered human tumor virus and is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and Multicentric Casttleman's disease. KSHV contains numerous open reading frames with striking homology to cellular genes. These viral gene products play a variety of roles in KSHV-associated pathogenesis by disrupting cellular signal transduction pathways, which include interferon-mediated anti-viral responses, cytokine-regulated cell growth, apoptosis, and cell cycle control. In this review, we will attempt to cover our understanding of how viral proteins deregulate cellular signaling pathways, which ultimately contribute to the conversion of normal cells to cancerous cells.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·B BiesingerB Fleckenstein
Nov 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M SchwemmleM Bachmann
Sep 1, 1992·The Journal of Experimental Medicine·H W MittrückerB Fleischer
Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·G R FosterG R Stark
Jan 15, 1989·International Journal of Cancer. Journal International Du Cancer·Q Y YaoA B Rickinson
Mar 16, 1989·The New England Journal of Medicine·N MuellerJ Vogelman
Apr 1, 1987·Annals of Internal Medicine·H Grierson, D T Purtilo
Oct 10, 1970·Lancet·A M Stewart
Jul 15, 1970·International Journal of Cancer. Journal International Du Cancer·G W Kafuko, D P Burkitt
Apr 29, 1967·British Medical Journal·M A EpsteinJ H Pope
Jan 1, 1982·Comparative Immunology, Microbiology and Infectious Diseases·G PizzaG B Cannon
May 4, 1995·The New England Journal of Medicine·E CesarmanD M Knowles
Jan 1, 1993·Annals of Internal Medicine·S E StrausJ Meier
Aug 1, 1996·Nature·Y ChangS Mittnacht
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·W ZhongD Ganem
Jun 1, 1996·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M Degré
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J A Lekstrom-HimesS E Straus
Jan 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·C V Sumaya
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·K AhnK Früh
Oct 15, 1996·Proceedings of the National Academy of Sciences of the United States of America·T R JonesH L Ploegh
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·J J RussoP S Moore
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·E H ChengJ M Hardwick
Jan 1, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·O SchatzF D Goebel
Dec 1, 1996·Cytokine & Growth Factor Reviews·D D Taub
Feb 15, 1997·Lancet·D H Adams, A R Lloyd
May 2, 1998·Science·H L Ploegh

❮ Previous
Next ❯

Citations

Mar 10, 2010·Molecules and Cells·Satoshi IshidoMari Ohmura-Hoshino
Mar 12, 2009·Journal of the National Cancer Institute·Zuzana BerkovaFelipe Samaniego
Feb 3, 2007·Infectious Agents and Cancer·Pawan PyakurelPeter Biberfeld
Aug 11, 2007·Reviews in Medical Virology·Masahiro FujimuroHideyoshi Yokosawa
Feb 9, 2008·American Journal of Hematology·Justin StebbingBruce J Dezube
Nov 8, 2012·Virology·Gail E Christie, Terje Dokland
Feb 11, 2009·Current Opinion in Immunology·Satoshi IshidoMari Ohmura-Hoshino
Aug 25, 2006·Journal of the International Association of Physicians in AIDS Care : JIAPAC·Justin StebbingMark Bower
Jun 16, 2016·MSphere·Kurtis M Host, Blossom Damania
Nov 1, 2018·Immunogenetics·Satoshi Ishido, Mizuho Kajikawa
Mar 26, 2003·Cell Death and Differentiation·J M Hardwick, D S Bellows
Sep 7, 2006·Journal of Biochemistry·Mari Ohmura-HoshinoSatoshi Ishido
Jul 3, 2003·Médecine sciences : M/S·Serge Bénichou, Alexandre Benmerah
Jul 1, 2020·Virus Research·Anna Bojagora, Vivian Saridakis
Apr 24, 2010·Virology·Liang-Tzung LinChristopher D Richardson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis