Molecular Players in Hematologic Tumor Cell Trafficking

Frontiers in Immunology
Javier Redondo-MuñozJoaquin Teixidó

Abstract

The trafficking of neoplastic cells represents a key process that contributes to progression of hematologic malignancies. Diapedesis of neoplastic cells across endothelium and perivascular cells is facilitated by adhesion molecules and chemokines, which act in concert to tightly regulate directional motility. Intravital microscopy provides spatio-temporal views of neoplastic cell trafficking, and is crucial for testing and developing therapies against hematologic cancers. Multiple myeloma (MM), chronic lymphocytic leukemia (CLL), and acute lymphoblastic leukemia (ALL) are hematologic malignancies characterized by continuous neoplastic cell trafficking during disease progression. A common feature of these neoplasias is the homing and infiltration of blood cancer cells into the bone marrow (BM), which favors growth and survival of the malignant cells. MM cells traffic between different BM niches and egress from BM at late disease stages. Besides the BM, CLL cells commonly home to lymph nodes (LNs) and spleen. Likewise, ALL cells also infiltrate extramedullary organs, such as the central nervous system, spleen, liver, and testicles. The α4β1 integrin and the chemokine receptor CXCR4 are key molecules for MM, ALL, and CLL cell traf...Continue Reading

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Citations

Feb 6, 2020·International Journal of Molecular Sciences·Rosa MolfettaRossella Paolini
Jun 6, 2020·The Journal of Pathology·Silvia Sevilla-MovillaJoaquin Teixidó
May 30, 2020·International Journal of Molecular Sciences·Paola Fernanda Ruiz-AparicioJean-Paul Vernot
Sep 15, 2020·Exploration of Targeted Anti-tumor Therapy·Rachael ArthurGraham Packham
Feb 15, 2020·Cancer Immunology, Immunotherapy : CII·Denise RisnikMirta Giordano
Dec 1, 2019·Cellular Signalling·Khanh T P NguyenDidier Dréau
Jan 12, 2021·Frontiers in Oncology·Hye Na KimYong-Mi Kim
Jan 14, 2021·Cancers·Almudena García-OrtizJoaquín Martínez-López
Mar 22, 2021·Journal of Hematology & Oncology·Zixi HongLiang Shao
Apr 13, 2021·Frontiers in Oncology·Vasileios LazarisKyriakos E Kypreos
May 21, 2021·Frontiers in Immunology·Francesca Vittoria SbranaCristina Scielzo

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Methods Mentioned

BETA
glycosylation
xenograft
xenografts
GTPase
antisense oligonucleotide
imaging techniques

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