Molecular population genetics of Drosophila subtelomeric DNA.

Genetics
Jennifer A AndersonCharles H Langley

Abstract

DNA sequence surveys in yeast and humans suggest that the forces shaping telomeric polymorphism and divergence are distinctly more dynamic than those in the euchromatic, gene-rich regions of the chromosomes. However, the generality of this pattern across outbreeding, multicellular eukaryotes has not been determined. To characterize the structure and evolution of Drosophila telomeres, we collected and analyzed molecular population genetics data from the X chromosome subtelomere in 58 lines of North American Drosophila melanogaster and 29 lines of African D. melanogaster. We found that Drosophila subtelomeres exhibit high levels of both structural and substitutional polymorphism relative to linked euchromatic regions. We also observed strikingly different patterns of variation in the North American and African samples. Moreover, our analyses of the polymorphism data identify a localized hotspot of recombination in the most-distal portion of the X subtelomere. While the levels of polymorphism decline sharply and in parallel with rates of crossing over per physical length over the distal first euchromatic megabase pairs of the X chromosome, our data suggest that they rise again sharply in the subtelomeric region (approximately 80 k...Continue Reading

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Citations

Jul 14, 2009·Genome Research·Célia PayenCécile Neuvéglise
Jan 1, 2008·Cytogenetic and Genome Research·G H Perry
Nov 6, 2008·Genetics·Jennifer A AndersonCharles H Langley
Mar 2, 2012·Genetics·Wynn K MeyerMolly Przeworski
Feb 4, 2014·Molecular Biology and Evolution·José L CamposBrian Charlesworth
Sep 25, 2014·Annual Review of Genetics·Brian Charlesworth, José L Campos
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May 1, 2019·Molecular Biology and Evolution·Jacob Carter CooperNitin Phadnis
Jul 6, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Helmut Plattner, Alexei Verkhratsky
May 2, 2017·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Amna Asif-LaidinLaure Teysset
Apr 19, 2017·Nature Genetics·Jia-Xing YueGianni Liti
May 10, 2015·Genetics·Matthew Z AndersonJudith Berman
Nov 5, 2019·Journal of Molecular Biology·Arpita SahaBibo Li
Mar 11, 2020·Trends in Genetics : TIG·Bastien Saint-Leandre, Mia T Levine
Jun 25, 2021·Nucleic Acids Research·Frédéric Chaux-JukicZhou Xu

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