Molecular portrait of breast cancer in China reveals comprehensive transcriptomic likeness to Caucasian breast cancer and low prevalence of luminal A subtype

Cancer Medicine
Xiaoyan HuangRosaria Orlandi

Abstract

The recent dramatic increase in breast cancer incidence across China with progressive urbanization and economic development has signaled the urgent need for molecular and clinical detailing of breast cancer in the Chinese population. Our analyses of a unique transethnic collection of breast cancer frozen specimens from Shanghai Fudan Cancer Center (Chinese Han) profiled simultaneously with an analogous Caucasian Italian series revealed consistent transcriptomic data lacking in batch effects. The prevalence of Luminal A subtype was significantly lower in Chinese series, impacting the overall prevalence of estrogen receptor (ER)-positive disease in a large cohort of Chinese/Caucasian patients. Unsupervised and supervised comparison of gene and microRNA (miRNA) profiles of Chinese and Caucasian samples revealed extensive similarity in the comprehensive taxonomy of transcriptional elements regulating breast cancer biology. Partition of gene expression data using gene lists relevant to breast cancer as "intrinsic" and "extracellular matrix" genes identified Chinese and Caucasian subgroups with equivalent global gene and miRNA profiles. These findings indicate that in the Chinese and Caucasian groups, breast neoplasia and the surroun...Continue Reading

References

Aug 30, 2000·Nature·C M PerouD Botstein
Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jan 14, 2003·Archives of Internal Medicine·Christopher I LiJanet R Daling
Jan 7, 2004·Nature Reviews. Cancer·John K Wiencke
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kathleen M EganWei Zheng
Feb 20, 2004·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Nicola M SuterElaine A Ostrander
Aug 26, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kun YuPatrick Tan
Oct 6, 2004·Genome Biology·Robert C GentlemanJianhua Zhang
May 2, 2006·Statistical Applications in Genetics and Molecular Biology·Gordon K Smyth
Jun 8, 2006·JAMA : the Journal of the American Medical Association·Lisa A CareyRobert C Millikan
Nov 30, 2007·The Journal of Pathology·A BergamaschiA-L Børresen-Dale
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
May 30, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Blase N PoliteEric P Winer
Dec 17, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·G A Thomas, R C F Leonard
Jan 21, 2009·Breast Cancer Research and Treatment·Lei FanZhi-Ming Shao
Feb 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Joel S ParkerPhilip S Bernard
Jan 26, 2010·Biostatistics·Matthew N McCallRafael A Irizarry
Sep 4, 2010·Breast Cancer Research : BCR·Aleix PratCharles M Perou
Dec 1, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carey K AndersCharles M Perou
Dec 29, 2010·Breast Cancer Research and Treatment·Jun WangJianshi Di
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Nov 24, 2011·Nucleic Acids Research·Aedín C CulhaneJohn Quackenbush
Feb 7, 2012·International Journal of Cancer. Journal International Du Cancer·Jue-Yu ZhouWen-Li Ma
Sep 25, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Oct 25, 2012·Journal of Translational Medicine·Chi-Cheng HuangEric Y Chuang
Oct 8, 2013·PloS One·Chi-Cheng HuangEric Y Chuang
Dec 4, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mariana Chavez-MacgregorAna M Gonzalez-Angulo
May 30, 2014·The Lancet Oncology·Lei FanPaul E Goss

❮ Previous
Next ❯

Citations

Mar 10, 2018·Journal of Cellular Physiology·Marta GiussaniElda Tagliabue
Nov 30, 2018·Journal of Cellular Physiology·Leimarembi Devi NaoremAmouda Venkatesan
Aug 24, 2017·PloS One·Silvia J Serrano-GómezJovanny Zabaleta
Jun 9, 2020·JCO Global Oncology·Gouri Shankar BhattacharyyaS P Somashekhar
Sep 17, 2020·ANZ Journal of Surgery·Alton HongMichael Law
May 12, 2018·Breast Cancer Research and Treatment·Shuyang WangXiao-Ou Shu

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE59595
GSE22219
GSE22216
GSE36772
GSE59590
GSE36722

Methods Mentioned

BETA
Chip
PCR
PCA

Software Mentioned

db
SubClass Mapping
limma
Illumina BeadStudio
Bioconductor
GenePattern
SubMap
illuminaHumanv3
pastecs

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Kun YuPatrick Tan
The Indian Journal of Public Administration : Quarterly Journal of the Indian Institute of Public Administration
M L Mehta
© 2021 Meta ULC. All rights reserved