Molecular profiles: a new tool to substantiate serum banks for evaluation of potential allergenicity of GMO

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D BarberG Salcedo

Abstract

Assessment of the allergenicity of GMOs involves performing a test with a panel of sera obtained from allergic donors. However, there is no clear indication of how to characterize the above-mentioned panel. The patient selection criteria should take into account the geographical location of patients, the intensity and nature of the environmental allergens in the area and the potential cross-reactivity among allergenic molecules. Sera for serum banks, obtained from patients with demonstrated food allergy, should be subjected to a further characterization by screening with a panel of relevant allergenic molecules. A representative panel of these sera should be used in the allergenicity assessment. Finally, the "in vitro" methodologies should have the adequate specificity and sensitivity, and the integrity of the molecules tested should be guaranteed.

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Citations

Aug 8, 2013·Methods : a Companion to Methods in Enzymology·Mayte VillalbaEva Batanero
May 9, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Karluss ThomasLaura Privalle

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