Molecular profiling and targeted therapy in pediatric gliomas: review and consensus recommendations.

Neuro-oncology
Zachary MikljaCarl Koschmann

Abstract

As the field of neuro-oncology makes headway in uncovering the key oncogenic drivers in pediatric glioma, the role of precision diagnostics and therapies continues to rapidly evolve with important implications for the standard of care for clinical management of these patients. Four studies at major academic centers were published in the last year outlining the clinically integrated molecular profiling and targeting of pediatric brain tumors; all 4 demonstrated the feasibility and utility of incorporating sequencing into the care of children with brain tumors, in particular for children and young adults with glioma. Based on synthesis of the data from these studies and others, we provide consensus recommendations for the integration of precision diagnostics and therapeutics into the practice of pediatric neuro-oncology. Our primary consensus recommendation is that next-generation sequencing should be routinely included in the workup of most pediatric gliomas.

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Citations

Jul 10, 2020·Neuro-oncology Advances·María Jesús Lobón-IglesiasEric Pasmant
Mar 14, 2020·Acta Neuropathologica Communications·Scott RyallCynthia Hawkins
Feb 8, 2020·Current Oncology Reports·Kyle WierzbickiCarl Koschmann
Dec 23, 2020·International Journal of Molecular Sciences·Santiago HaaseMaria G Castro
Mar 31, 2021·Neurosurgery Clinics of North America·Sophie M PeetersAnthony C Wang
Jul 11, 2021·World Neurosurgery·Rajiv S MaggeHoward A Fine

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