Molecular profiling distinguishes papillary carcinoma from benign thyroid nodules

The Journal of Clinical Endocrinology and Metabolism
David J FinleyThomas J Fahey

Abstract

Recently we identified a molecular basis for differentiating benign and malignant follicular thyroid tumors. The purpose of these studies was to determine whether molecular analysis can be used to differentiate papillary thyroid carcinomas from benign thyroid nodules. Gene expression patterns of 14 papillary thyroid carcinomas and 21 benign tumors were analyzed by oligonucleotide array analysis. The carcinomas included seven classical papillary thyroid carcinomas (PTC) and seven follicular variant of PTC (FVPTC), and the benign tumors included 14 follicular adenomas and seven hyperplastic nodules. A hierarchical clustering analysis was performed to examine the groups for potential differences. The combined PTC and FVPTC groups had a distinct gene expression profile compared with the benign lesions. The sensitivity for a diagnosis of carcinoma was 93%, with a 100% specificity (one FVPTC clustered with the benign nodules). Cancer gene profiles contained both known (Met and galectin-3) and previously unidentified genes. Gene profiling is a reliable means of distinguishing PTC, FVPTC, and benign tumors of the thyroid. These gene profiles may provide insight into the pathogenesis of papillary thyroid carcinoma and may ultimately enh...Continue Reading

Citations

Jul 20, 2010·Langenbeck's Archives of Surgery·Arturs OzolinsJanis Gardovskis
May 14, 2005·Virchows Archiv : an International Journal of Pathology·Bogdan GaluscaMichel Peoc'h
Jun 13, 2008·Endocrine Pathology·Stefano Serra, Sylvia L Asa
Dec 7, 2007·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G Riesco-Eizaguirre, P Santisteban
Jul 1, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yao-Tseng ChenTheresa Scognamiglio
Sep 26, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Michel R NasrAnna-Luise A Katzenstein
Jul 31, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Karen M DenningOrla M Sheils
Sep 1, 2011·Nature Reviews. Endocrinology·Yuri E Nikiforov, Marina N Nikiforova
Jan 1, 2010·Nutrition and Cancer·Meredith A KatoThomas J Fahey
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·David J FinleyThomas J Fahey
Jul 21, 2005·Thyroid : Official Journal of the American Thyroid Association·Susanne DiehlMartha A Zeiger
Jul 18, 2008·Thyroid : Official Journal of the American Thyroid Association·Sven SaussezGuy Laurent
Aug 21, 2004·Annals of Surgery·David J FinleyThomas J Fahey
Nov 29, 2007·Current Opinion in Oncology·Daniel ShibruElectron Kebebew
Jan 7, 2009·Current Opinion in Oncology·Michael T Stang, Sally E Carty
Feb 27, 2010·Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B·Anna KundelThomas J Fahey
Mar 1, 2012·Pathology International·Kennichi KakudoTakashi Ozaki
May 6, 2006·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mårten FryknäsAnders Isaksson
May 10, 2008·Annals of Surgical Oncology·Katsuya SakashitaMasaki Mori
Mar 23, 2011·Annals of Surgical Oncology·Meredith A KatoRasa Zarnegar
Jan 29, 2013·Journal of Molecular Endocrinology·Maria Rossing
Nov 7, 2008·Endocrine-related Cancer·Robert C SmallridgeJohn A Copland
Mar 19, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Marek Niedziela
Mar 11, 2008·World Journal of Surgery·Nimmi AroraThomas J Fahey
Sep 12, 2008·World Journal of Surgery·Martha A Zeiger
Jan 15, 2015·Molecular Medicine Reports·Xinyong ZhuWen Tian
Jul 5, 2011·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·M SchlumbergerF de Vathaire
Mar 23, 2011·Human Pathology·Michelle D WilliamsAdel K El-Naggar
Oct 20, 2009·The Surgical Clinics of North America·Meredith A Kato, Thomas J Fahey
Jan 1, 2015·Nature Reviews. Disease Primers·Henning DralleSteven I Sherman
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Yolanda C Oertel
May 26, 2005·Brain Pathology·Brianna N StillmanLinda G Baum
Dec 21, 2007·The Laryngoscope·Nitin A PagedarPierre Lavertu

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