Molecular profiling of colorectal tumors stratified by the histological tumor-stroma ratio - Increased expression of galectin-1 in tumors with high stromal content

Oncotarget
Tessa P SandbergHans Morreau

Abstract

The tumor microenvironment is a dominant determinant of cancer cell behavior. Reactive tumor stroma is associated with poor outcome perspective. The tumor-stroma ratio (TSR) is a strong independent prognostic factor in colorectal cancer and is easily assessed using conventional hematoxylin and eosin (H&E) stained paraffin sections at the invasive margin of the tumor. We aim to understand the biology of the tumor stroma in colorectal cancer by investigating the transcriptomic profiles of tumors classified by the TSR method. The TSR was assessed in a cohort of 71 colorectal cancer patients undergoing surgery without (neo)adjuvant therapy. In the cohort, stroma-high tumors were distinguished from stroma-low tumors at gene expression level in the upregulation of biological pathways related to extracellular matrix (ECM) remodeling and myogenesis. The activated microenvironment in stroma-high tumors overexpressed different types of collagen genes, THBS2 and 4 as well as INHBA, COX71A and LGALS1/galectin-1. The upregulation of THBS2, COX7A1 and LGALS1/galectin-1. The upregulation of THBS2, COX7A1 and LGALS1/galectin-1 in stroma-high tumors was validated in The Cancer Genome Atlas. In conclusion, the gene expression data reflects the h...Continue Reading

References

Mar 23, 2000·Cardiovascular Research·E P MoiseevaD P de Bono
Dec 7, 2002·Nature Genetics·Sridhar RamaswamyTodd R Golub
Dec 10, 2002·International Journal of Cancer. Journal International Du Cancer·Axel HitteletIsabelle Camby
Dec 25, 2003·Bioinformatics·Jelle J GoemanHans C van Houwelingen
Jan 20, 2005·Bioinformatics·Jelle J GoemanHans C van Houwelingen
Jun 29, 2007·Journal of the National Cancer Institute·Cornelis J A PuntJean-Yves Douillard
Jan 19, 2008·The American Journal of Pathology·Victor L ThijssenArjan W Griffioen
Apr 15, 2009·Nature Reviews. Immunology·Gabriel A Rabinovich, Marta A Toscano
May 30, 2009·Cellular Oncology : the Official Journal of the International Society for Cellular Oncology·Wilma E MeskerHans J Tanke
Apr 27, 2010·Nature Cell Biology·Louis VermeulenJan Paul Medema
Apr 28, 2010·Gastroenterology·C Richard Boland, Ajay Goel
Nov 26, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramon SalazarRob Tollenaar
Dec 3, 2010·Journal of Cell Science·Christian FrantzValerie M Weaver
Apr 27, 2011·International Journal of Cancer. Journal International Du Cancer·Hannah BarrowLu-Gang Yu
Apr 14, 2012·Statistical Applications in Genetics and Molecular Biology·Jelle J Goeman, Livio Finos
Jul 20, 2012·Nature·UNKNOWN Cancer Genome Atlas Network
Jul 31, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kai WangYufeng Cheng
Aug 7, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A HuijbersW E Mesker
Jun 7, 2013·BMC Cancer·Arantza Fariña SarasquetaHans Morreau
Oct 12, 2013·Nature Communications·Kosuke YoshiharaRoel G W Verhaak
Jan 15, 2014·Seminars in Cancer Biology·A CalonE Batlle
Jan 25, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J H ParkC S D Roxburgh
Jun 15, 2014·Experimental Cell Research·Min Jin LimJie-Young Song
Feb 24, 2015·Nature Genetics·Claudio IsellaEnzo Medico
Feb 24, 2015·Nature Genetics·Alexandre CalonEduard Batlle
Oct 13, 2015·Nature Medicine·Justin GuinneySabine Tejpar
Jan 16, 2016·Cell Systems·Arthur LiberzonPablo Tamayo
Mar 20, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Etienne BechtWolf Herman Fridman
May 7, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Philip D DunneSandra Van Schaeybroeck
Jul 28, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne TrinhLouis Vermeulen
Sep 17, 2016·Scientific Reports·Xue WangMaode Lai
Feb 15, 2018·Nature·Daniele V F TaurielloEduard Batlle

❮ Previous
Next ❯

Citations

Jun 28, 2019·Journal of Pathology and Translational Medicine·Dmitry Aleksandrovich ZinovkinMd Zahidul Islam Pranjol
Apr 10, 2020·International Journal of Cancer. Journal International Du Cancer·Andreas SchlickerLoredana Vecchione
Oct 28, 2019·Combinatorial Chemistry & High Throughput Screening·Fahimeh FattahiMohammad Najafi
May 6, 2021·International Journal of Molecular Sciences·Yulia I NussbaumJonathan B Mitchem

❮ Previous
Next ❯

Software Mentioned

R package ESTIMATE
GlobalTest
R package
ESTIMATE Populations -
ESTIMATE

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.