Molecular Profiling Reveals a Clonal Relationship Between Ovarian Mucinous Tumors and Corresponding Mural Carcinomatous Nodules

The American Journal of Surgical Pathology
Nima Mesbah ArdakaniColin J Stewart

Abstract

Benign or malignant mural nodules rarely occur in mucinous tumors (MTs) of the ovary and malignant nodules can show mesenchymal or epithelial differentiation. The histogenesis of mural nodules is unclear and it has been suggested that these may evolve through divergent differentiation of the mucinous neoplasm or alternatively represent a collision phenomenon. To test these possibilities we compared the molecular profile of 7 ovarian MTs with their matched mural carcinomatous nodules (MCNs) by next-generation sequencing. We found identical KRAS mutations in paired MTs and MCNs in 6 cases, one of which also showed identical CDH1 mutations in both components. In 1 tumor a KRAS mutation was detected in the mucinous neoplasm but not in the MCN; however, identical p53 mutations were present in both tumor elements. Unpaired p53 and PTEN mutations were detected only in the MCN in 2 cases, while mutations in p53 and PIK3CA genes were observed only in the MT in 2 cases. The overall comparative genomic profile was consistent with the neoplastic nature of the MCNs and strongly supported their clonal relationship with the more differentiated mucinous neoplasms. MCNs possibly develop through the acquisition of additional genomic alterations,...Continue Reading

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Citations

Jun 13, 2019·The New England Journal of Medicine·David R SpriggsNida Safdar
Aug 8, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David B ChapelMarisa R Nucci
Sep 5, 2018·Journal of Ovarian Research·Toshiyuki OkumuraMasanori Maruyama
May 26, 2018·International Journal of Molecular Sciences·Francesca RicciGiovanna Damia
Dec 17, 2020·Seminars in Diagnostic Pathology·Jennifer A Bennett, Esther Oliva
Apr 11, 2021·BMJ Case Reports·Alicia HunterHooman Soleymani Majd

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