Molecular Programming of Biodegradable Nanoworms via Ionically Induced Morphology Switch toward Asymmetric Therapeutic Carriers

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Shoupeng CaoDavid S Williams

Abstract

Engineering biodegradable nanostructures with precise morphological characteristics is a key objective in nanomedicine. In particular, asymmetric (i.e., nonspherical) nanoparticles are desirable due to the advantageous effects of shape in a biomedical context. Using molecular engineering, it is possible to program unique morphological features into the self-assembly of block copolymers (BCPs). However, the criteria of biocompatibility and scalability limit progress due to the prevalence of nondegradable components and the use of toxic solvents during fabrication. To address this shortfall, a robust strategy for the fabrication of morphologically asymmetric nanoworms, comprising biodegradable BCPs, has been developed. Modular BCPs comprising poly (ethylene glycol)-block-poly(caprolactone-gradient-trimethylene carbonate) (PEG-PCLgTMC), with a terminal chain of quaternary ammonium-TMC (PTMC-Q), undergo self-assembly via direct hydration into well-defined nanostructures. By controlling the solution ionic strength during hydration, particle morphology switches from spherical micelles to nanoworms (of varying aspect ratio). This ionically-induced switch is driven by modulation of chain packing with salts screening interchain repulsio...Continue Reading

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Citations

Feb 16, 2021·ACS Applied Materials & Interfaces·Marleen H M E van StevendaalJan C M van Hest
Apr 8, 2021·Nature Communications·Shoupeng CaoJan C M van Hest
May 24, 2021·Advanced Drug Delivery Reviews·Neha KapateSamir Mitragotri
Mar 27, 2020·Biomacromolecules·Roxane RidolfoDavid S Williams
Oct 24, 2019·Biomacromolecules·Yigit AltayJan C M van Hest

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