PMID: 18406257Apr 15, 2008Paper

Molecular Properties of the CRF Receptor

Trends in Endocrinology and Metabolism : TEM
J SpiessJ Radulovic

Abstract

Research into the biology of corticotropin-releasing factor (CRF) has been intensified significantly by the structural characterization of the CRF receptor (CRF-R). Two receptor subtypes, CRF-R1 and CRF-R2, and three functional splice variants of CRF-R2 have been discovered. It appears that ligand binding requires interaction of the N-terminal domain with one or two other extracellular domains of the CRF-R. In contrast to the mammalian CRF-R1, the frog CRF-R1 discriminates between naturally occurring CRF-like peptides.

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Jan 19, 2000·Pharmacology, Biochemistry, and Behavior·R F ParrottJ A Goode
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