Molecular recognition and function of riboswitches.

Current Opinion in Structural Biology
Alexander Serganov, Dinshaw J Patel

Abstract

Regulatory mRNAs elements termed riboswitches respond to elevated concentrations of cellular metabolites by modulating expression of associated genes. Riboswitches attain their high metabolite selectivity by capitalizing on the intrinsic tertiary structures of their sensor domains. Over the years, riboswitch structure and folding have been amongst the most researched topics in the RNA field. Most recently, novel structures of single-ligand and cooperative double-ligand sensors have broadened our knowledge of architectural and molecular recognition principles exploited by riboswitches. The structural information has been complemented by extensive folding studies, which have provided several important clues on the formation of ligand-competent conformations and mechanisms of ligand discrimination. These studies have greatly improved our understanding of molecular events in riboswitch-mediated gene expression control and provided the molecular basis for intervention into riboswitch-controlled genetic circuits.

References

Sep 23, 2006·Science·Daniel J Klein, Adrian R Ferré-D'Amaré
Oct 4, 2007·Proceedings of the National Academy of Sciences of the United States of America·Jane N KimRonald R Breaker
Jan 22, 2008·Biochemistry·Benoit Heppell, Daniel A Lafontaine
Jul 3, 2008·The Journal of Biological Chemistry·Andrew D GarstRobert T Batey
Nov 15, 2008·Journal of Molecular Biology·Andrea L Edwards, Robert T Batey
Feb 24, 2009·Nature Structural & Molecular Biology·Daniel J KleinAdrian R Ferré-D'Amaré
Mar 6, 2009·The Journal of Biological Chemistry·Robert C SpitaleJoseph E Wedekind
Mar 24, 2009·Current Opinion in Structural Biology·Alexander Serganov
Sep 11, 2009·ACS Chemical Biology·Jane N KimRonald R Breaker
Nov 10, 2009·Nature Structural & Molecular Biology·Kathryn D SmithScott A Strobel
Nov 10, 2009·Nature Structural & Molecular Biology·Nadia KulshinaAdrian R Ferré-D'Amaré
Nov 21, 2009·Journal of Molecular Biology·Mona AliSebastian Doniach
Dec 22, 2009·Nucleic Acids Research·Vanessa DelfossePascale Legault
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·Neil DixonJason Micklefield
Feb 18, 2010·ACS Chemical Biology·Liuhong ChenChris Abell
Apr 28, 2010·PLoS Pathogens·Jérôme MulhbacherDaniel A Lafontaine
May 5, 2010·Proceedings of the National Academy of Sciences of the United States of America·Mi-Kyung LeeGabriele Varani
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ulrike RiederRonald Micura
Jul 20, 2010·Structure·Colby D StoddardRobert T Batey
Aug 10, 2010·Biochemistry·Kathryn D SmithScott A Strobel
Nov 16, 2010·Journal of Molecular Biology·Ross C WilsonMark P Foster
Nov 26, 2010·Nucleic Acids Research·Scott P Hennelly, Karissa Y Sanbonmatsu
Feb 15, 2011·Nature Structural & Molecular Biology·Peter Y Watson, Martha J Fedor
Mar 3, 2011·Biochemistry·Desirae Leipply, David E Draper
Mar 29, 2011·Chemistry & Biology·Ethan B ButlerScott A Strobel
Mar 29, 2011·Chemistry & Biology·Peter DaldropRuth Brenk
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kathryn D SmithScott A Strobel
May 3, 2011·Nature Chemical Biology·Andrea HallerRonald Micura
May 3, 2011·Nature Chemical Biology·Benoit HeppellDaniel A Lafontaine
May 18, 2011·Nucleic Acids Research·Anna WackerHarald Schwalbe
May 20, 2011·The Journal of Biological Chemistry·Jermaine L JenkinsJoseph E Wedekind
Jun 17, 2011·The Journal of Biological Chemistry·Renaud TremblayDaniel A Lafontaine
Aug 16, 2011·Nature Chemical Biology·Olga PikovskayaAlexander Serganov
Aug 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lili HuangAlexander Serganov
Sep 20, 2011·Molecular Cell·Ronald R Breaker
Dec 24, 2011·Science·Jenny L BakerRonald R Breaker

❮ Previous
Next ❯

Citations

Oct 22, 2013·International Journal of Medical Microbiology : IJMM·Christina E LünseGünter Mayer
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrea HallerRonald Micura
May 25, 2013·PLoS Computational Biology·Wei HuangFareed Aboul-ela
Jun 7, 2013·Mobile DNA·Annica Hedberg, Steinar D Johansen
Dec 20, 2015·Biophysical Journal·Julie L Sutton, Lois Pollack
Dec 22, 2015·Nucleic Acids Research·Michal J BonieckiJanusz M Bujnicki
Mar 15, 2016·Journal of the American Chemical Society·Marina Frener, Ronald Micura
Mar 4, 2014·Biochimica Et Biophysica Acta·Alla Peselis, Alexander Serganov
Aug 19, 2015·Nature Structural & Molecular Biology·Christopher P Jones, Adrian R Ferré-D'Amaré
Mar 19, 2013·Plant Science : an International Journal of Experimental Plant Biology·Ian M SilvermanBrian D Gregory
Apr 19, 2016·Cell·Caleb WeinrebDebora S Marks
Aug 4, 2015·The Journal of Chemical Physics·Sha GongWenbing Zhang
Apr 27, 2013·RNA Biology·Efrat Kligun, Yael Mandel-Gutfreund
Apr 25, 2013·RNA Biology·Kaila Deiorio-HaggarMichelle M Meyer
May 3, 2014·RNA Biology·Marcin MagnusJanusz M Bujnicki
Feb 1, 2015·Trends in Biochemical Sciences·Zachary T Campbell, Marvin Wickens
Jan 13, 2015·The Journal of Chemical Physics·Sha GongWenbing Zhang
Aug 19, 2016·Frontiers in Chemistry·Cibran Perez-GonzalezJ Carlos Penedo
Dec 13, 2016·Nature Chemical Biology·Vishnu ChandraMaumita Mandal
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·Marie F SoulièreRonald Micura
Jun 8, 2017·ACS Synthetic Biology·Christopher SchneiderBeatrix Suess
Jul 14, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sha GongWenbing Zhang
Apr 3, 2015·Microbiology and Molecular Biology Reviews : MMBR·Christopher A VakulskasTony Romeo
Oct 10, 2013·Nature Reviews. Molecular Cell Biology·Sarah Geisler, Jeff Coller
May 21, 2019·Nucleic Acids Research·Ashok NuthanakantiSeergazhi G Srivatsan
Jun 24, 2014·Chembiochem : a European Journal of Chemical Biology·Julia E WeigandBeatrix Suess
Sep 27, 2014·Angewandte Chemie·Stephanie A Barros, David M Chenoweth
Apr 21, 2020·Current Protocols in Nucleic Acid Chemistry·Ashok Nuthanakanti, Seergazhi G Srivatsan
Mar 1, 2019·Nature Reviews. Molecular Cell Biology·Markus M RinschenGary Siuzdak
Mar 8, 2017·Proceedings of the National Academy of Sciences of the United States of America·Zasha WeinbergRonald R Breaker
Jan 9, 2013·Angewandte Chemie·Marie F SoulièreRonald Micura
Mar 7, 2014·The Journal of Biological Chemistry·Yixin ShiWei Kong
Aug 8, 2018·Nucleic Acids Research·Saki MatsumotoKazuhiko Nakatani
Sep 19, 2020·Chemical Society Reviews·Ronald Micura, Claudia Höbartner
Dec 23, 2020·Chembiochem : a European Journal of Chemical Biology·Abdallah S AbdelsattarFareed Aboul-Ela
Feb 10, 2021·Journal of Chemical Theory and Computation·Dong ZhangShi-Jie Chen

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.