Molecular Recognition by a Short Partial Peptide of the Adrenergic Receptor: A Bottom-Up Approach

Angewandte Chemie
Tsubasa SekiguchiMasaaki Fujii

Abstract

Receptor-neurotransmitter molecular recognition is key for neurotransmission. Although crystal structures of the receptors are known, the mechanism for recognition is not clear. Reported here is the ultraviolet (UV) and infrared (IR) spectra of complexes between a partial peptide (SIVSF), mimicking the binding motif of a catechol ring in the adrenergic receptor, and various ligands. The UV spectra show that two isomers coexist in the complex of SIVSF with properly recognized ligands, such as protonated adrenaline (adrenalineH+ ). From IR spectra, they are assigned to catechol- and amino-bound structures. The catechol-bound structure is not observed when the ligand is replaced by nonproper molecules, such as noradrenalineH+ . The results suggest that SIVSF not only recognizes the catechol ring but can distinguish differences in the amine side chain. The method provides a new possibility for screening molecules as potential therapeutics for activating the receptor.

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Citations

Feb 14, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Masaaki FujiiShun-Ichi Ishiuchi
Mar 18, 2020·Physical Chemistry Chemical Physics : PCCP·Hiroya Nakata, Cheol Ho Choi
Mar 30, 2019·Angewandte Chemie·Erik SaparbaevOleg V Boyarkin
Mar 7, 2019·The Journal of Physical Chemistry Letters·Masato TamuraMasaaki Fujii
Feb 8, 2019·Journal of Chemical Theory and Computation·Kiyoshi YagiYuji Sugita
Sep 10, 2021·Journal of Oleo Science·Daisuke Sakemi, Satoshi Horikoshi

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