Molecular Recognition Features in Zika Virus Proteome

Journal of Molecular Biology
Pushpendra Mani MishraRajanish Giri

Abstract

Viruses have compact genomes that encode limited number of proteins in comparison to other biological entities. Interestingly, viral proteins have shown natural abundance of either completely disordered proteins that are recognized as intrinsically disorder proteins (IDPs) or partially disordered segments known as intrinsically disordered protein regions (IDPRs). IDPRs are involved in interactions with multiple binding partners to accomplish signaling, regulation, and control functions in cells. Tuning of IDPs and IDPRs are mediated through post-translational modification and alternative splicing. Often, the interactions of IDPRs with their binding protein partner(s) lead to transition from the state of disorder to ordered form. Such interaction-prone protein IDPRs are identified as molecular recognition features (MoRFs). Molecular recognition is an important initial step for the biomolecular interactions and their functional proceedings. Although previous studies have established occurrence of the IDPRs in Zika virus proteome, which provide the functional diversity and structural plasticity to viral proteins, the MoRF analysis has not been performed as of yet. Many computational methods have been developed for the identificati...Continue Reading

Citations

Nov 9, 2019·Biomolecules·Gerard Kian-Meng GohVladimir N Uversky
May 31, 2020·The FEBS Journal·Taniya BhardwajRajanish Giri
Nov 7, 2019·Journal of Biomolecular Structure & Dynamics·Deepak KumarRajanish Giri
Sep 13, 2020·Biological Reviews of the Cambridge Philosophical Society·Munishwar Nath Gupta, Ipsita Roy
Jan 3, 2020·Cellular and Molecular Life Sciences : CMLS·Kundlik GadhaveRajanish Giri
Nov 18, 2018·Cellular and Molecular Life Sciences : CMLS·Elrashdy M RedwanVladimir N Uversky
Apr 13, 2018·Scientific Reports·Ankur SinghRajanish Giri
Nov 23, 2019·Journal of Biomolecular Structure & Dynamics·Prateek KumarRajanish Giri
Jul 28, 2020·Cellular and Molecular Life Sciences : CMLS·Rajanish GiriVladimir N Uversky
Apr 27, 2018·Frontiers in Molecular Neuroscience·Yeny Acosta-AmpudiaCarolina Ramírez-Santana
May 30, 2020·Viruses·Luis Adrián De Jesús-GonzálezRosa María Del Ángel
Jan 12, 2021·Journal of Proteome Research·Shalini AggarwalSanjeeva Srivastava
May 1, 2021·Viruses·Luis Adrián De Jesús-GonzálezRosa María Del Ángel
Jul 1, 2021·Current Research in Virological Science·Amit KumarRajanish Giri
Jan 8, 2019·ACS Omega·Ankur KumarRajanish Giri
Aug 29, 2019·ACS Omega·Denzelle L LyngdohTimir Tripathi
Feb 23, 2020·Journal of Proteome Research·Shayli Varasteh MoradiKirill Alexandrov
Aug 14, 2020·Biochimica Et Biophysica Acta. Biomembranes·Kumar Udit SaumyaRajanish Giri

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