Molecular regulation of an invasion-related molecule--options for tumour staging and clinical strategies

European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Heike Allgayer

Abstract

This review provides a summary of the European Association for Cancer Research Award Lecture, presented at the ECCO13 meeting in Paris in November 2005. It is a brief overview on the biological and clinical relevance of the urokinase receptor (u-PAR), an essential molecule to promote invasive and metastatic tumour phenotype and shown to be associated with early relapse and poor prognosis in many different types of cancers. The review summarizes the most important transcriptional mechanisms regulating u-PAR gene, and will focus on the differential binding of transcription factors to u-PAR promoter elements from studies in resected tumour and normal tissues of colorectal and gastric cancer patients. These studies conducted by our group may help to understand transcriptional mechanisms, which are employed to promote invasion and metastasis, in subpopulations of cancer patients. Such studies could lead to a more target-oriented patient selection and therapy against transcriptional and oncogeneic regulators in cancer.

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Citations

Sep 15, 2007·Journal of Gastroenterology and Hepatology·Yan Jie Zhang, Jing Yuan Fang
Mar 1, 2007·PloS One·Margarita GutovaKaren S Aboody
Oct 15, 2009·Journal of Cancer Research and Clinical Oncology·Francesca CeccarelliSigfrido Scarpa
Apr 7, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Heike Allgayer
Oct 20, 2009·Critical Reviews in Oncology/hematology·Heike Allgayer
Oct 7, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Heike Allgayer, Julio A Aguirre-Ghiso
Feb 6, 2009·Biotechnology Progress·Shilpa S KhapardeAsok Mukhopadhyay

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