PMID: 9187053Jan 1, 1997Paper

Molecular regulation of cytokine gene expression: interferon-gamma as a model system

Progress in Nucleic Acid Research and Molecular Biology
H A Young, P Ghosh

Abstract

The regulation of IFN-gamma transcription appears to be quite complex. In addition to the interaction of numerous regions of the genomic DNA with multiple DNA binding protein family members, DNA methylation may serve to act as an early determinant of the capacity of a cell to initiate transcription. Transcriptional activation occurs in response to both soluble extracellular signals and cell contact, and it appears quite likely that this activation may result from the interaction of different families of DNA binding proteins with different enhancer elements. Furthermore, because chronic IFN-gamma transcription and subsequent expression would likely be detrimental to the host (see 81), mechanisms have evolved to quench expression at both transcriptional and posttranscriptional levels. Given the complexity of cell-to cell interactions in the immune system, it is reasonable to expect that additional mechanisms regulating IFN-gamma transcription, involving previously identified or as yet unidentified DNA binding proteins, remain to be defined.

Citations

Aug 24, 1999·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·V GiedraitisJ Hillert
Jan 23, 2003·The Journal of Experimental Medicine·Huei-Wei ChanCharles T Lutz
Oct 6, 2019·Life Science Alliance·William J CrislerLaurel L Lenz
Dec 26, 2001·The Journal of Biological Chemistry·Lisa A SchubertDavid B Lewis
Feb 16, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·David E LevyArun Prakash
Nov 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christophe ChevillardAlain J Dessein
Jan 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·C K LeeD E Levy
Feb 26, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Paulo Marcelo, François Lefèvre
Nov 18, 2004·Immunological Reviews·Sidney PestkaMark R Walter
Sep 13, 2006·Journal of Leukocyte Biology·Katy WendtRoland Jacobs
Dec 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Benjamin R WindersDenis Bruniquel
Dec 29, 1998·Biochimie·F LefèvreC La Bonnardière

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