Molecular regulation of mammalian hepatic architecture

Current Topics in Developmental Biology
Stacey S Huppert, Makiko Iwafuchi-Doi

Abstract

The essential liver exocrine and endocrine functions require a precise spatial arrangement of the hepatic lobule consisting of the central vein, portal vein, hepatic artery, intrahepatic bile duct system, and hepatocyte zonation. This allows blood to be carried through the liver parenchyma sampled by all hepatocytes and bile produced by the hepatocytes to be carried out of the liver through the intrahepatic bile duct system composed of cholangiocytes. The molecular orchestration of multiple signaling pathways and epigenetic factors is required to set up lineage restriction of the bipotential hepatoblast progenitor into the hepatocyte and cholangiocyte cell lineages, and to further refine cell fate heterogeneity within each cell lineage reflected in the functional heterogeneity of hepatocytes and cholangiocytes. In addition to the complex molecular regulation, there is a complicated morphogenetic choreography observed in building the refined hepatic epithelial architecture. Given the multifaceted molecular and cellular regulation, it is not surprising that impairment of any of these processes can result in acute and chronic hepatobiliary diseases. To enlighten the development of potential molecular and cellular targets for thera...Continue Reading

Citations

Dec 6, 2019·World Journal of Gastroenterology : WJG·Fernanda de Oliveira LemosM Fatima Leite
Jan 11, 2021·Development, Growth & Differentiation·Wendy L Thompson, Takanori Takebe
Feb 7, 2021·Development·Lillian B SpatzJason C Mills
Nov 12, 2020·Diagnostics·Mohammed D Ayoub, Binita M Kamath
Jul 31, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Jonathan B SteinmanUtpal B Pajvani
Sep 4, 2021·Development·Stephanie A CampbellPamela A Hoodless

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