Molecular regulation of postsynaptic differentiation at the neuromuscular junction

IUBMB Life
Raghavan Madhavan, H Benjamin Peng

Abstract

The neuromuscular junction (NMJ) is a synapse that develops between a motor neuron and a muscle fiber. A defining feature of NMJ development in vertebrates is the re-distribution of muscle acetylcholine (ACh) receptors (AChRs) following innervation, which generates high-density AChR clusters at the postsynaptic membrane and disperses aneural AChR clusters formed in muscle before innervation. This process in vivo requires MuSK, a muscle-specific receptor tyrosine kinase that triggers AChR re-distribution when activated; rapsyn, a muscle protein that binds and clusters AChRs; agrin, a nerve-secreted heparan-sulfate proteoglycan that activates MuSK; and ACh, a neurotransmitter that stimulates muscle and also disperses aneural AChR clusters. Moreover, in cultured muscle cells, several additional muscle- and nerve-derived molecules induce, mediate or participate in AChR clustering and dispersal. In this review we discuss how regulation of AChR re-distribution by multiple factors ensures aggregation of AChRs exclusively at NMJs.

References

Jul 1, 1976·Journal of Neurobiology·C Edwards, H L Frisch
Apr 1, 1992·Neuron·K W TsimU J McMahan
Jan 1, 1990·Cold Spring Harbor Symposia on Quantitative Biology·U J McMahan
Jan 1, 1985·Annual Review of Neuroscience·M M Poo
Mar 1, 1986·Experimental Cell Research·R SealockK Burridge
May 1, 1988·The Journal of Cell Biology·A EntwistleS Bevan
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S J Burden
Apr 1, 1986·The Journal of Cell Biology·R J Bloch
Apr 1, 1995·Physiological Reviews·A Duclert, J P Changeux
Feb 17, 1995·The Journal of Biological Chemistry·G TsenG J Cole
May 17, 1996·Cell·D J GlassG D Yancopoulos
Oct 1, 1996·Current Opinion in Cell Biology·M D Henry, K P Campbell
Jan 1, 1996·Molecular and Cellular Neurosciences·D F DaggettH B Peng
Apr 1, 1997·Current Opinion in Neurology·V Straub, K P Campbell
Jun 1, 1997·Current Opinion in Neurobiology·D J Glass, G D Yancopoulos
Oct 6, 1997·The Journal of Cell Biology·J E SugiyamaZ W Hall
Oct 23, 1997·Current Opinion in Neurology·M Michalak, M Opas
Jan 1, 1997·Molecular and Cellular Neurosciences·H ZhouH B Peng
Nov 22, 1997·Journal of Neurocytology·H B PengZ Dai
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M K Ramarao, J B Cohen

❮ Previous
Next ❯

Citations

Aug 2, 2013·Journal of the International Neuropsychological Society : JINS·Christopher RandolphKevin Guskiewicz
May 27, 2011·Molecular Biology of the Cell·Pan P LiH Benjamin Peng
Jun 1, 2012·Molecular Biology of the Cell·Cheng ChenH Benjamin Peng
Jul 17, 2009·BMC Neuroscience·Lin GengH Benjamin Peng
Nov 3, 2011·PloS One·Hailong Luke Zhang, H Benjamin Peng
Mar 19, 2014·Gene·Fabrício M LopesRoberto M Cesar
Aug 13, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Yung-Fu ChangShao-Tung Liu
Nov 28, 2012·Cellular and Molecular Life Sciences : CMLS·Yinong Zong, Rongsheng Jin
May 1, 2007·Trends in Neurosciences·Sean D Speese, Vivian Budnik
Jul 31, 2007·Developmental Neurobiology·Xiaotao T ZhaoH Benjamin Peng
Aug 23, 2012·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Pan P LiH Benjamin Peng
Jun 3, 2008·Chemico-biological Interactions·Lin GengH Benjamin Peng
Jan 18, 2015·Neuroscience Letters·Wei Song, Xiwan Albert Jin
Sep 11, 2012·Neurobiology of Disease·Lyndsay M MurrayRashmi Kothary
Oct 13, 2006·Journal of Neurobiology·Raghavan MadhavanH Benjamin Peng
Dec 30, 2006·The Journal of Biological Chemistry·Tiziana CrepaldiCarola Ponzetto
Oct 12, 2013·Annual Review of Pharmacology and Toxicology·Cody J WenthurCraig W Lindsley
Jun 12, 2019·International Journal of Molecular Sciences·Serena MaggioMichele Guescini
Dec 22, 2020·Frontiers in Molecular Neuroscience·Pedro M Rodríguez CruzAngela Vincent

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.