Molecular regulation of striatal development: a review.

Anatomy Research International
A E EvansA E Rosser

Abstract

The central nervous system is composed of the brain and the spinal cord. The brain is a complex organ that processes and coordinates activities of the body in bilaterian, higher-order animals. The development of the brain mirrors its complex function as it requires intricate genetic signalling at specific times, and deviations from this can lead to brain malformations such as anencephaly. Research into how the CNS is specified and patterned has been studied extensively in chick, fish, frog, and mice, but findings from the latter will be emphasised here as higher-order mammals show most similarity to the human brain. Specifically, we will focus on the embryonic development of an important forebrain structure, the striatum (also known as the dorsal striatum or neostriatum). Over the past decade, research on striatal development in mice has led to an influx of new information about the genes involved, but the precise orchestration between the genes, signalling molecules, and transcription factors remains unanswered. We aim to summarise what is known to date about the tightly controlled network of interacting genes that control striatal development. This paper will discuss early telencephalon patterning and dorsal ventral patternin...Continue Reading

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Citations

May 6, 2014·Experimental Neurology·Erica SarchielliGabriella B Vannelli
Jan 24, 2014·Developmental Neurobiology·Yi-Chi ChiuTsu-Wei Wang
Mar 6, 2013·Molecular and Cellular Neurosciences·Julia A Kaye, Steven Finkbeiner
Oct 16, 2015·Brain Research·Virginia B Mattis, Clive N Svendsen
Dec 19, 2014·Frontiers in Cellular Neuroscience·Amy E ReddingtonStephen B Dunnett
Sep 30, 2015·Molecular Therapy. Methods & Clinical Development·Marco StracciaJosep M Canals
Aug 28, 2020·Frontiers in Cellular Neuroscience·Cristina Salado-ManzanoJosep M Canals
Dec 4, 2019·Frontiers in Neuroscience·Michel Modo
Apr 12, 2012·Experimental Biology and Medicine·Sophie V Precious, Anne E Rosser

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