Molecular regulation of the developing commissural plate.

The Journal of Comparative Neurology
Randal X MoldrichLinda J Richards

Abstract

Coordinated transfer of information between the brain hemispheres is essential for function and occurs via three axonal commissures in the telencephalon: the corpus callosum (CC), hippocampal commissure (HC), and anterior commissure (AC). Commissural malformations occur in over 50 human congenital syndromes causing mild to severe cognitive impairment. Disruption of multiple commissures in some syndromes suggests that common mechanisms may underpin their development. Diffusion tensor magnetic resonance imaging revealed that forebrain commissures crossed the midline in a highly specific manner within an oblique plane of tissue, referred to as the commissural plate. This specific anatomical positioning suggests that correct patterning of the commissural plate may influence forebrain commissure formation. No analysis of the molecular specification of the commissural plate has been performed in any species; therefore, we utilized specific transcription factor markers to delineate the commissural plate and identify its various subdomains. We found that the mouse commissural plate consists of four domains and tested the hypothesis that disruption of these domains might affect commissure formation. Disruption of the dorsal domains occu...Continue Reading

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Citations

Feb 7, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·James M CleggThomas Pratt
Sep 29, 2011·Yi chuan = Hereditas·Yan-Yan QianDuan Ma
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May 8, 2021·Seminars in Cell & Developmental Biology·Laura R FenlonLinda J Richards
Mar 10, 2011·Current Opinion in Neurology

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