Molecular regulation of the hypothalamo-pituitary-adrenal axis in streptozotocin-induced diabetes: effects of insulin treatment

Endocrinology
Owen ChanStephen G Matthews

Abstract

Increased hypothalamo-pituitary-adrenocortical (HPA) activity in diabetes is likely important in the development of some pathologies associated with the disorder. We hypothesized that central regulation of HPA activity differs among normal, streptozotocin (STZ)-diabetic, and insulin-treated diabetic rats. Blood glucose, ACTH, and corticosterone were elevated, 8 d after inducing diabetes. Insulin treatment normalized these parameters. Plasma norepinephrine was similar in all groups, but epinephrine was lower in STZ-diabetic and higher in insulin-treated rats vs. normals. Increased ACTH with diabetes corresponded with increased hypothalamic CRH mRNA, but no change in pituitary POMC mRNA. With insulin-treatment, CRH mRNA remained elevated, and POMC mRNA was unaltered. Hippocampal MR mRNA expression was dramatically increased with diabetes and, moreover, was not normalized by insulin. No differences in GR mRNA were detected between normal and STZ-diabetic rats. However, insulin treatment increased GR mRNA levels in the paraventricular nucleus and pituitary. We postulate that, in STZ-diabetes: 1) increased HPA activity is caused by increased central drive at and/or above the level of the paraventricular nucleus and is associated wit...Continue Reading

Citations

Aug 4, 2004·Psychopharmacology·Shigeo MiyataJunzo Kamei
Jun 30, 2015·Canadian Journal of Physiology and Pharmacology·Maha Mohamed ElBatsh
Apr 6, 2004·Biochemical and Biophysical Research Communications·Katsutaka OishiNorio Ishida
Jan 17, 2017·Physiology & Behavior·Rebecca L EricksonIrwin Lucki
Sep 27, 2018·International Journal of Experimental Pathology·Soumia HammadiYasmina Dahmani
Oct 16, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Darleen A SandovalStephen N Davis
Jul 6, 2014·Translational Neurodegeneration·Angel GolimstokEdgardo Cristiano
Mar 19, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Owen ChanMladen Vranic
Dec 18, 2010·Bulletin of Experimental Biology and Medicine·N V KuznetsovaV A Shkurupiy
Sep 8, 2005·American Journal of Physiology. Endocrinology and Metabolism·Dóra ZelenaGábor B Makara
Nov 10, 2006·American Journal of Physiology. Cell Physiology·Adam P W JohnstonThomas J Hawke
Feb 21, 2008·American Journal of Physiology. Endocrinology and Metabolism·Karine BédardPierrette Gaudreau
Jan 23, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yusuke TozukaKeiji Wada
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mladen Vranic
May 15, 2002·American Journal of Physiology. Endocrinology and Metabolism·Karen InouyeMladen Vranic
Oct 14, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Edward ParkMichael C Riddell
May 16, 2019·Journal of Cellular Biochemistry·Saber BarsiahAmirhossein Sahebkar
Apr 16, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jonathan E CampbellMichael C Riddell
Jan 1, 2020·Journal of Diabetes and Metabolic Disorders·Mona A MohamedRasha A El Sayed
Oct 21, 2004·American Journal of Physiology. Endocrinology and Metabolism·Karen E InouyeMladen Vranic
Mar 28, 2013·American Journal of Physiology. Endocrinology and Metabolism·Manuel Gil-LozanoFederico Mallo
Sep 1, 2016·Irish Journal of Psychological Medicine·C DolanB Lawlor
Feb 27, 2021·Journal of Neuroendocrinology·Sasha Rawlinson, Zane B Andrews

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.