Molecular responses in the telomere-mitochondrial axis of ageing in the elderly: a candidate gene approach

Mechanisms of Ageing and Development
Nicky PietersTim S Nawrot

Abstract

Experimental evidence shows that telomere shortening induces mitochondrial damage but so far studies in humans are scarce. Here, we investigated the association between leukocyte telomere length (LTL) and mitochondrial DNA (mtDNA) content in elderly and explored possible intermediate mechanisms by determining the gene expression profile of candidate genes in the telomere-mitochondrial axis of ageing. Among 166 non-smoking elderly, LTL, leukocyte mtDNA content and expression of candidate genes: sirtuin1 (SIRT1), tumor protein p53 (TP53), peroxisome proliferator-activated receptor γ-coactivator1α (PGC-1α), peroxisome proliferator-activated receptor γ-coactivator1β (PGC-1β), nuclear respiratory factor 1 (NRF1) and nuclear factor, erythroid 2 like 2 (NRF2), using a quantitave real time polymerase chain assay (qPCR). Statistical mediation analysis was used to study intermediate mechanisms of the telomere-mitochondrial axis of ageing. LTL correlated with leukocyte mtDNA content in our studied elderly (r = 0.23, p = 0.0047). SIRT1 gene expression correlated positively with LTL (r = 0.26, p = 0.0094) and leukocyte mtDNA content (r = 0.43, p < 0.0001). The other studied candidates showed significant correlations in the telomere-mitochon...Continue Reading

References

Apr 18, 1991·Nature·E H Blackburn
Aug 30, 2000·Lancet·D Hochhauser
Dec 6, 2001·Diabetes Research and Clinical Practice·Y S ChoiY K Pak
May 29, 2002·Biochimica Et Biophysica Acta·Richard C Scarpulla
Jul 31, 2002·Circulation·Scott W BallingerMarschall S Runge
Feb 7, 2004·Carcinogenesis·David MeierhoferWolfgang Sperl
Mar 9, 2004·Genes & Development·Daniel P Kelly, Richard C Scarpulla
May 14, 2005·Genes, Chromosomes & Cancer·Chew-Wun WuHsin-Chen Lee
Jun 21, 2005·Family Practice·Stefaan BartholomeeusenFrank Buntinx
Jan 26, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brett G MasayesvaJoseph Califano
Apr 26, 2007·Molecular Endocrinology·Hiroyasu YamamotoJohan Auwerx
Jul 31, 2008·Journal of the National Cancer Institute·Jinliang XingXifeng Wu
Dec 9, 2008·The Biochemical Journal·Michael P Murphy
Oct 22, 2009·American Journal of Physiology. Endocrinology and Metabolism·Subir K Roy ChowdhuryGarry X Shen
May 12, 2010·Circulation·Robert D BrookUNKNOWN American Heart Association Council on Epidemiology and Prevention, Council on the Kidney in Cardiovascular Disease, and Coun
Jun 15, 2010·Environmental and Molecular Mutagenesis·Pingfang Liu, Bruce Demple
Jun 15, 2010·Environmental and Molecular Mutagenesis·Douglas C Wallace
Aug 11, 2010·Environmental Health : a Global Access Science Source·Lifang HouAndrea Baccarelli
Dec 29, 2010·The Journal of Cell Biology·Jose A PalaciosMaria A Blasco
Apr 7, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ingrid M WentzensenSharon A Savage
Sep 6, 2011·Environmental Health : a Global Access Science Source·Valérie PennemansQuirine Swennen
Oct 19, 2011·Environmental Health Perspectives·Michele CarugnoAndrea Baccarelli
May 26, 2012·Environmental Health Perspectives·Bram G JanssenTim S Nawrot
Jun 16, 2012·Particle and Fibre Toxicology·Stephan T SternRachael M Crist
Jul 13, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Bharat ThyagarajanJian-Min Yuan
Sep 5, 2012·Biological Chemistry·Wen-Xing Ding, Xiao-Ming Yin
Jul 26, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Sofia PavanelloAndrea A Baccarelli
Dec 25, 2013·BMC Public Health·Esmée BijnensTim S Nawrot
May 13, 2014·BioMed Research International·Dimitry A ChistiakovYuri V Bobryshev
Jul 10, 2014·BMJ : British Medical Journal·Philip C HaycockPeter Willeit

❮ Previous
Next ❯

Citations

Dec 26, 2015·American Journal of Epidemiology·Judita KnezTatiana Kuznetsova
Mar 25, 2017·Mitochondrial DNA. Part A. DNA Mapping, Sequencing, and Analysis·Egija ZoleRenate Ranka
Jun 26, 2017·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Xiao WangJan Sundquist
Mar 1, 2018·Biogerontology·Egija Zole, Renāte Ranka
Mar 16, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonas Mengel-FromLene Christiansen
Apr 30, 2020·Proceedings. Biological Sciences·Lauren E GyllenhammerPathik D Wadhwa
Feb 2, 2018·Psychosomatic Medicine·Martin Picard, Bruce S McEwen
Jul 22, 2018·Clinical Oral Investigations·Ching-Chi LinMei-Wei Lin
Jul 29, 2020·International Journal of Molecular Sciences·Evelyn FerriBeatrice Arosio
Jan 17, 2017·International Journal of Epidemiology·Bram G JanssenTim S Nawrot
Feb 1, 2020·The Science of the Total Environment·Citlalli Osorio-YáñezMartine Vrijheid
May 20, 2021·Oxidative Medicine and Cellular Longevity·Chuanbin LiuYang Li
Jul 14, 2021·International Journal of Sports Medicine·Samuel S AguiarHerbert G Simões

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Aging

This feed focuses on cellular aging with emphasis on mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Aging Genetics (Keystone)

This feed focuses on aging epidemiology and genetic, epigenetic, and proteomic aspects underlying aging, as well as aging- associated biomarkers. Here the latest research in this domain.

Aging-Associated Metabolic Disorders

Age is associated with many metabolic disorders including cardiovascular diseases, type 2 diabetes, stroke and heart disease. The mediators in aging process have been suggested to play a part in the cellular processes responsible for these metabolic disorders. Here is the latest research on aging-associated metabolic disorders.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Epidemiology of Aging

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Aging & Diabetes

This feed focuses on the role of the aging process on developing diabetes.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Aging Epidemiology

This feed focuses on epidemiology of aging and aging-related conditions, including Alzheimer’s disease, dementia, and age-associated cognitive impairment. Here is the latest research.

Cell Aging (Keystone)

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.