Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes

Cold Spring Harbor Perspectives in Medicine
Shailja Singh, Chetan E Chitnis

Abstract

During the blood stage, Plasmodium spp. merozoites invade host red blood cells (RBCs), multiply, exit, and reinvade uninfected RBCs in a continuing cycle that is responsible for all the clinical symptoms associated with malaria. Entry into (invasion) and exit from (egress) RBCs are highly regulated processes that are mediated by an array of parasite proteins with specific functional roles. Many of these parasite proteins are stored in specialized apical secretory vesicles, and their timely release is critical for successful invasion and egress. For example, the discharge of parasite protein ligands to the apical surface of merozoites is required for interaction with host receptors to mediate invasion, and the timely discharge of proteases and pore-forming proteins helps in permeabilization and dismantling of limiting membranes during egress. This review focuses on our understanding of the signaling mechanisms that regulate apical organelle secretion during host cell invasion and egress by malaria parasites. The review also explores how understanding key signaling mechanisms in the parasite can open opportunities to develop novel strategies to target Plasmodium parasites and eliminate malaria.

References

Aug 5, 1976·The New England Journal of Medicine·L H MillerM H McGinniss
Feb 28, 1975·Science·J A DvorakT Shiroishi
Feb 23, 1999·Molecular Microbiology·V B Carruthers, L D Sibley
Aug 30, 2001·The Journal of Biological Chemistry·R MoudyC J Beckers
Oct 19, 2001·Molecular and Biochemical Parasitology·L M Alleva, K Kirk
Jul 15, 2003·The Journal of Biological Chemistry·Mark E WickhamAlan F Cowman
Aug 28, 2003·Current Opinion in Microbiology·Silvia N J Moreno, Roberto Docampo
Mar 9, 2004·International Journal for Parasitology·Helen I WiersmaRobert G K Donald
Sep 2, 2004·Cellular Microbiology·Michael J Blackman
Aug 10, 2005·Blood Cells, Molecules & Diseases·Shivani SoniManjit Hanspal
Feb 25, 2006·Cell·Alan F Cowman, Brendan S Crabb
Jul 3, 2007·Transactions of the Royal Society of Tropical Medicine and Hygiene·Carlos Eugênio CavasiniRicardo Luiz Dantas Machado
Nov 13, 2007·Eukaryotic Cell·Mark D Lavine, Gustavo Arrizabalaga
Jan 1, 2008·The Journal of Biological Chemistry·Ankush VaidPushkar Sharma
May 28, 2008·Cellular Microbiology·Michael J Blackman
Sep 5, 2008·The Journal of Biological Chemistry·Judith L GreenAnthony A Holder
Oct 28, 2008·International Journal for Parasitology·Paul R Gilson, Brendan S Crabb
Jul 21, 2009·Cellular Microbiology·Marijo S Roiko, Vern B Carruthers
Sep 26, 2009·PLoS Pathogens·Robert W MoonOliver Billker
Jan 9, 2010·Annual Review of Pharmacology and Toxicology·Martijn Gloerich, Johannes L Bos
Mar 17, 2010·Proceedings of the National Academy of Sciences of the United States of America·Didier MénardPeter A Zimmerman
Jun 12, 2010·Communicative & Integrative Biology·Björn F C Kafsack, Vern B Carruthers
Sep 22, 2010·Proceedings of the National Academy of Sciences of the United States of America·Wai-Hong ThamAlan F Cowman
Feb 8, 2011·Blood·Manouk AbkarianCatherine Braun-Breton
May 4, 2011·Cellular Microbiology·Sébastien BesteiroMaryse Lebrun
Jul 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Prakash SrinivasanLouis H Miller
Aug 2, 2011·Current Opinion in Microbiology·Deepak Gaur, Chetan E Chitnis
Sep 10, 2011·Molecular & Cellular Proteomics : MCP·Melanie G MillhollandDoron C Greenbaum

❮ Previous
Next ❯

Citations

May 11, 2020·Cellular Microbiology·Anat FlorentinVasant Muralidharan
Feb 19, 2017·Cold Spring Harbor Perspectives in Medicine·Caeul LimManoj T Duraisingh
Jan 26, 2020·Nature Reviews. Microbiology·Joachim M MatzMichael J Blackman
Dec 5, 2020·Molecular Microbiology·Brendan Elsworth, Manoj T Duraisingh
Aug 21, 2021·Frontiers in Cellular and Infection Microbiology·Vitomir DjokicNikhat Parveen
Aug 25, 2021·Current Opinion in Microbiology·Benedito M Dos SantosCélia Rs Garcia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.