Molecular signatures of lung cancer: defining new diagnostic and therapeutic paradigms.

Molecular Diagnosis & Therapy
Justin M Balko, Carlos L Arteaga

Abstract

Molecular profiling holds great promise for improving our ability to diagnose, prognosticate, and select individualized treatments for lung cancer patients. However, using multidimensional data and novel technologies to derive these profiles is limited by our ability to employ the assay in a clinical scenario where it can impact the course of disease. Although many molecular signatures have been reported in lung cancer, as of yet, few have been sufficiently validated for widespread clinical use. Recently, several novel signatures have been reported, which address critical aspects of patient care and/or demonstrate improved efforts for appropriate clinical validation. Here, we present our opinion on the current state of the field of molecular signatures in lung cancer.

References

Aug 1, 1995·The Annals of Thoracic Surgery·J C NesbittC F Mountain
Jul 16, 2002·Nature Medicine·David G BeerSamir Hanash
Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Dec 14, 2004·The New England Journal of Medicine·Soonmyung PaikNorman Wolmark
Jun 24, 2005·The New England Journal of Medicine·Timothy WintonUNKNOWN National Cancer Institute of the United States Intergroup JBR.10 Trial Investigators
Jun 3, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Lan GuoYong Qian
Aug 1, 2006·Molecular Cancer Research : MCR·Christopher D ColdrenPaul A Bunn
Sep 8, 2006·The New England Journal of Medicine·Ken A OlaussenUNKNOWN IALT Bio Investigators
Nov 4, 2006·Carcinogenesis·Jill Everland LarsenKwun Meng Fong
May 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jill E LarsenKwun M Fong
Dec 11, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Suzanne K LauMing-Sound Tsao
Feb 19, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zhifu SunPing Yang
May 29, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre PignonUNKNOWN LACE Collaborative Group
Jul 22, 2008·Nature Medicine·UNKNOWN Director's Challenge Consortium for the Molecular Classification of Lung AdenocarcinomaDavid G Beer
Aug 5, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Marcin SkrzypskiRafael Rosell
Sep 4, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dan J RazDavid M Jablons
Jan 2, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Paul RoepmanNico van Zandwijk
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Paul C BoutrosIgor Jurisica
May 16, 2009·Clinical Lung Cancer·Johannes R Kratz, David M Jablons
Aug 21, 2009·The New England Journal of Medicine·Rafael RosellUNKNOWN Spanish Lung Cancer Group
Dec 26, 2009·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Joseph M AmannDavid P Carbone
Dec 30, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Yves DouillardEdward S Kim
Mar 18, 2010·Journal of the National Cancer Institute·Jyothi Subramanian, Richard Simon
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Sep 9, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chang-Qi ZhuMing-Sound Tsao
Nov 10, 2010·Journal of Proteome Research·Joana CarrolaIola F Duarte
Dec 18, 2010·The Lancet Oncology·Lars Petter JordheimCharles Dumontet
Dec 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Humam KadaraReuben Lotan
Jan 11, 2011·Nature Medicine·Anil PottiJoseph R Nevins
Jun 21, 2011·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jul 13, 2011·Journal of Proteome Research·Cláudia M RochaIola F Duarte
Sep 6, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Koichi AzumaMasayoshi Kage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.