How distinct stem cell populations originate and whether there is a clear stem cell "genetic signature" remain poorly understood. Understanding the evolution of stem cells requires molecular profiling of stem cells in an animal at a basal phylogenetic position. In this study, using transgenic Hydra polyps, we reveal for each of the three stem cell populations a specific signature set of transcriptions factors and of genes playing key roles in cell type-specific function and interlineage communication. Our data show that principal functions of stem cell genes, such as maintenance of stemness and control of stem cell self-renewal and differentiation, arose very early in metazoan evolution. They are corroborating the view that stem cell types shared common, multifunctional ancestors, which achieved complexity through a stepwise segregation of function in daughter cells.
Systematic isolation of peptide signal molecules regulating development in hydra: LWamide and PW families
Budhead, a fork head/HNF-3 homologue, is expressed during axis formation and head specification in hydra
Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation.
EST analysis of the cnidarian Acropora millepora reveals extensive gene loss and rapid sequence divergence in the model invertebrates
Basic leucine zipper transcription factors C/EBP and MafL in the hydrozoan jellyfish Podocoryne carnea
TReP-132 controls cell proliferation by regulating the expression of the cyclin-dependent kinase inhibitors p21WAF1/Cip1 and p27Kip1
Control of foot differentiation in Hydra: phylogenetic footprinting indicates interaction of head, bud and foot patterning systems
A wide-range phylogenetic analysis of Zic proteins: implications for correlations between protein structure conservation and body plan complexity
Transgenic stem cells in Hydra reveal an early evolutionary origin for key elements controlling self-renewal and differentiation
A phylostratigraphy approach to uncover the genomic history of major adaptations in metazoan lineages
Cell type complexity in the basal metazoan Hydra is maintained by both stem cell based mechanisms and transdifferentiation
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells
Compagen, a comparative genomics platform for early branching metazoan animals, reveals early origins of genes regulating stem-cell differentiation
Concatenated analysis sheds light on early metazoan evolution and fuels a modern "urmetazoon" hypothesis.
Plasticity of epithelial cell shape in response to upstream signals: a whole-organism study using transgenic Hydra
Hydra meiosis reveals unexpected conservation of structural synaptonemal complex proteins across metazoans.
Deep sequencing reveals unique small RNA repertoire that is regulated during head regeneration in Hydra magnipapillata
RNAseq versus genome-predicted transcriptomes: a large population of novel transcripts identified in an Illumina-454 Hydra transcriptome
Evidence for involvement of Wnt signalling in body polarities, cell proliferation, and the neuro-sensory system in an adult ctenophore
RNA-Seq of the Caribbean reef-building coral Orbicella faveolata (Scleractinia-Merulinidae) under bleaching and disease stress expands models of coral innate immunity
Epigenomic Co-localization and Co-evolution Reveal a Key Role for 5hmC as a Communication Hub in the Chromatin Network of ESCs
Complex transcriptional regulation and independent evolution of fungal-like traits in a relative of animals
Neurogenesis in an early protostome relative: progenitor cells in the ventral nerve center of chaetognath hatchlings are arranged in a highly organized geometrical pattern
Loss of neurogenesis in Hydra leads to compensatory regulation of neurogenic and neurotransmission genes in epithelial cells
How do environmental factors influence life cycles and development? An experimental framework for early-diverging metazoans
Interspecific Differential Expression Analysis of RNA-Seq Data Yields Insight into Life Cycle Variation in Hydractiniid Hydrozoans
The Role of Complement in Cnidarian-Dinoflagellate Symbiosis and Immune Challenge in the Sea Anemone Aiptasia pallida
The evolutionally-conserved function of group B1 Sox family members confers the unique role of Sox2 in mouse ES cells.
Transitioning from Microbiome Composition to Microbial Community Interactions: The Potential of the Metaorganism Hydra as an Experimental Model
Evolutionary hallmarks of the human proteome: chasing the age and coregulation of protein-coding genes
A widely employed germ cell marker is an ancient disordered protein with reproductive functions in diverse eukaryotes
Differential responses to Wnt and PCP disruption predict expression and developmental function of conserved and novel genes in a cnidarian
Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra
Cell-Type Transcriptomes of the Multicellular Green Alga Volvox carteri Yield Insights into the Evolutionary Origins of Germ and Somatic Differentiation Programs
Inducible aging in Hydra oligactis implicates sexual reproduction, loss of stem cells, and genome maintenance as major pathways.
Phylogenies of central element proteins reveal the dynamic evolutionary history of the mammalian synaptonemal complex: ancient and recent components
Adult Stem Cells
Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.