Molecular size cutoff criteria for screening bioaccumulation potential: fact or fiction?

Integrated Environmental Assessment and Management
Jon A ArnotPat Doyle

Abstract

It has been asserted that, when screening chemicals for bioaccumulation potential, molecular size cutoff criteria (or indicators) can be applied above which no, or limited, bioaccumulation is expected. The suggested molecular size values have increased over time as more measurements have become available. Most of the proposed criteria have been derived from unevaluated fish bioconcentration factor (BCF) data, and less than 5% of existing organic substances have measured BCFs.We critically review the proposed criteria, first by considering other factors that may also contribute to reduced bioaccumulation for larger molecules, namely, reduced bioavailability in the water column, reduced rate of uptake corresponding to reduced diffusion rates, and the effects of biotransformation and growth dilution. An evaluated BCF and bioaccumulation factor (BAF) database for more than 700 substances and dietary uptake efficiency data are compared against proposed cutoff values. We examine errors associated with interpreting BCF data, particularly for developing molecular size criteria of bioaccumulation potential. Reduced bioaccumulation that is often associated with larger molecular size can be explained by factors other than molecular size, ...Continue Reading

Citations

Mar 26, 2016·Environmental Science & Technology·David M WaltersPeter Leipzig-Scott
Apr 5, 2014·The Science of the Total Environment·Li M SuYuan H Zhao
Jan 14, 2016·Environment International·Francesca GrisoniRoberto Todeschini
Mar 4, 2020·Integrated Environmental Assessment and Management·Adam LillicrapScott E Belanger
Jul 20, 2019·Environmental Science & Technology·Mafalda CastroMagnus Breitholtz
May 15, 2018·Environmental Science & Technology·Xiaoying LiLei Wang
Nov 30, 2018·Environmental Science & Technology·Donald MackayJ Mark Parnis

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