Molecular species of phosphoglycerides in liver microsomes of rats fed a fat-free diet

Lipids
H A GardaR R Brenner

Abstract

The influence of a fat-free diet on the molecular species composition of phosphatidylcholine (PC), phosphatidylethanolamine (PE), and phosphatidylinositol (PI) of rat liver microsomes was studied by using reversed-phase high-pressure liquid chromatography. In the three phosphoglyceride classes analyzed, the fat-free diet produced a large decrease in the 18:0/20:4n-6 species but less important changes were found in the 16:0/20:4n-6 species. In PC, the most abundant phosphoglyceride class of rat liver microsomes, the fall in the 18:0/20:4n-6 species was counterbalanced mainly by an enhancement in the 16:0/18:1n-9 species although it was not evident in PE. In PI, the decrease in the 18:0/20:4n-6 species was counterbalanced by an increase in the 18:0/20:3n-9 species. Fluorescence polarization measurements of 1,7-diphenyl-1,3,5-hexatriene in liposomes of 16:0/18:1n-9, 18:0/18:1n-9-, 16:0/20:4n-6-, and 18:0/20:4n-6-PC indicated that the change in the saturated fatty acid in the sn-1 position accompanying the replacement of 20:4n-6 by 18:1n-9 could be very important for a homeoviscous compensation, maintaining the membrane physical properties without large alterations in spite of the essential fatty acid deficiency due to the fat-free...Continue Reading

References

Sep 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J Orly, M Schramm
Oct 31, 1989·Molecular and Cellular Biochemistry·J L Soulages, R R Brenner
Jan 1, 1986·Progress in Lipid Research·A G LeeR J Froud
Nov 1, 1965·The Journal of Nutrition·Q R Rogers, A E Harper
Jan 1, 1983·World Review of Nutrition and Dietetics·H S Hansen
Jan 1, 1981·Annals of the New York Academy of Sciences·J Axelrod, F Hirata

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