Jan 15, 2014

Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments

PLoS Genetics
Jungeui Hong, David Gresham

Abstract

One of the central goals of evolutionary biology is to explain and predict the molecular basis of adaptive evolution. We studied the evolution of genetic networks in Saccharomyces cerevisiae (budding yeast) populations propagated for more than 200 generations in different nitrogen-limiting conditions. We find that rapid adaptive evolution in nitrogen-poor environments is dominated by the de novo generation and selection of copy number variants (CNVs), a large fraction of which contain genes encoding specific nitrogen transporters including PUT4, DUR3 and DAL4. The large fitness increases associated with these alleles limits the genetic heterogeneity of adapting populations even in environments with multiple nitrogen sources. Complete identification of acquired point mutations, in individual lineages and entire populations, identified heterogeneity at the level of genetic loci but common themes at the level of functional modules, including genes controlling phosphatidylinositol-3-phosphate metabolism and vacuole biogenesis. Adaptive strategies shared with other nutrient-limited environments point to selection of genetic variation in the TORC1 and Ras/PKA signaling pathways as a general mechanism underlying improved growth in nut...Continue Reading

  • References73
  • Citations30

Mentioned in this Paper

Saccharomyces cerevisiae Proteins
Zinc Fingers
Flow Cytometry
Biochemical Pathway
Glucose Metabolism Disorders
VAC14 gene
Phosphatidylinositols
Gene Dosage
Heuristics
Histidine

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