Molecular stool screening for colorectal cancer

The British Journal of Surgery
T MakJ Hill

Abstract

Mass screening for colorectal cancer reduces mortality and, with recent advances in molecular genetics, molecular stool-based tests have produced promising results. This article reviews this innovation and discusses its clinical significance. Medline searches were used to identify recent key articles relating to stool-based testing. Further articles were obtained by manual scanning of the reference lists of identified papers. Current screening methods are based on endoscopic, radiological and stool-based testing. Recent recognition of the adenoma-carcinoma sequence and pathophysiological studies of colonic epithelium have enabled tumour markers to be used in the screening setting. Non-invasive molecular stool testing has now been shown to have a high sensitivity and specificity. Recent studies on molecular stool-based testing have shown higher sensitivity and specificity than earlier studies, but larger clinical trials are required. Laboratory methods are still undergoing research, with the aim of improving sensitivity to allow large-scale testing.

References

Sep 30, 1992·International Journal of Cancer. Journal International Du Cancer·G P AlbaughP P Nair
Sep 17, 1992·Nature·S M PowellK W Kinzler
Jul 2, 1992·Nature·D P Lane
Jun 1, 1990·Cell·E R Fearon, B Vogelstein
Apr 14, 1989·Science·B VogelsteinR White
Mar 1, 1989·Klinische Wochenschrift·P HerzogK H Holtermüller
Sep 1, 1988·The New England Journal of Medicine·B VogelsteinJ L Bos
Jan 1, 1987·Annual Review of Biochemistry·M Barbacid
Feb 1, 1984·British Journal of Cancer·M J TurunenH Adlercreutz
Sep 25, 1995·Nucleic Acids Research·R DeuterO Müller
Feb 1, 1995·Current Opinion in Genetics & Development·P Polakis
Dec 1, 1993·Scandinavian Journal of Gastroenterology·A G RøsethB Roald
Jan 1, 1993·Annals of Clinical Biochemistry·A MoranP Asquith
Jun 19, 1993·International Journal of Cancer. Journal International Du Cancer·D M ParkinJ Ferlay
Jan 1, 1995·Advances in Experimental Medicine and Biology·P BrandtzaegM K Fagerhol
Dec 1, 1995·Digestive Diseases and Sciences·A MoranJ D Hardcastle
Dec 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P RozenN Papo
May 3, 1996·International Journal of Cancer. Journal International Du Cancer·P NollauC Wagener
Oct 1, 1996·Scandinavian Journal of Gastroenterology·J A GilbertR D Ellefson
Nov 1, 1996·Diseases of the Colon and Rectum·C RattoF Crucitti
Feb 1, 1997·Gastroenterology·S J WinawerR J Mayer
May 1, 1997·Gastroenterology·W S Samowitz, M L Slattery
Jun 1, 1997·Molecular Pathology : MP·B JohneI Dale
Dec 31, 1997·Hospital Practice·C R Boland
Mar 26, 1998·Diseases of the Colon and Rectum·J KristinssonK Nygaard
Aug 14, 1998·Current Opinion in Oncology·H T Lynch, T Smyrk
Sep 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D G Kirsch, M B Kastan

❮ Previous
Next ❯

Citations

Oct 17, 2007·Langenbeck's Archives of Surgery·Jens K HabermannUwe J Roblick
Sep 25, 2007·International Journal of Clinical Practice·A Loganayagam
Nov 8, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andrea N Burnett-HartmanJohn D Potter
Sep 13, 2012·Gastroenterology Research and Practice·Rani KanthanSelliah Chandra Kanthan
Feb 26, 2016·British Journal of Cancer·Anita AnnaháziRichárd Róka
Oct 27, 2007·Annals of Emergency Medicine·Bruce D AdamsJoanne Dabulewicz
Dec 13, 2006·Radiologic Clinics of North America·Marc J GollubTim Akhurst
Nov 14, 2008·NMR in Biomedicine·Daniel MonleónBernardo Celda
Dec 5, 2008·Scottish Medical Journal·S A Goodbrand, R J C Steele
Aug 3, 2011·Journal of Biomolecular Screening·Stefanie BüngerUNKNOWN BMBF-Consortium "Colorectal Cancer Screening Chip"
Mar 30, 2006·World Journal of Gastroenterology : WJG·Zhi-Zhong PanFu-Long Wang
Jun 1, 2017·Expert Review of Molecular Diagnostics·Manish Pratap SinghSameer Srivastava
Aug 25, 2005·Acta Oncologica·Matti HakamaLars Påhlman
Jun 29, 2006·The Medical Journal of Australia·Shyr-Chyr ChenWei-Jao Chen
Nov 18, 2005·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G FerrettiF Cognetti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Ernest T Hawk, Bernard Levin
The New England Journal of Medicine
Thomas F ImperialeColorectal Cancer Study Group
The New England Journal of Medicine
Bert VogelsteinJ L Bos
© 2022 Meta ULC. All rights reserved