Molecular strategies used by fish pathogens to interfere with host-programmed cell death

Developmental and Comparative Immunology
María P SepulcreVictoriano Mulero

Abstract

Cell death is of pivotal importance in the regulation of the immune response and has a direct impact in disease resistance. Fish are becoming an interesting model organism to study the immune response since they hold a key phylogenetic position and many species are of high economic interest. The role of cell death in the immune response has recently been investigated in fish and the molecules and pathways orchestrating cell death in this group of animals have begun to be elucidated. In this study, we will summarize the different molecular strategies displayed by major fish bacterial and viral pathogens to interfere with programmed cell death of the host as well as the relevance of cell death in the resolution of the infectious diseases caused by these pathogens.

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Citations

Aug 29, 2013·Developmental and Comparative Immunology·Bertrand Collet
Sep 13, 2015·Fish & Shellfish Immunology·Amparo Estepa, Julio Coll
Jan 23, 2013·Microbial Biotechnology·Jonathan A CrayJohn E Hallsworth

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