PMID: 8600460Mar 1, 1996Paper

Molecular structure of a gypsy element of Drosophila subobscura (gypsyDs) constituting a degenerate form of insect retroviruses

Nucleic Acids Research
T M Alberola, R de Frutos

Abstract

We have determined the nucleotide sequence of a 7.5 kb full-size gypsy element from Drosophila subobscura strain H-271. Comparative analyses were carried out on the sequence and molecular structure of gypsy elements of D.subobscura (gypsyDs), D.melanogaster (gypsyDm) and D.virilis (gypsyDv). The three elements show a structure that maintains a common mechanism of expression. ORF1 and ORF2 show typical motifs of gag and pol genes respectively in the three gypsy elements and could encode functional proteins necessary for intracellular expansion. In the three ORF1 proteins an arginine-rich region was found which could constitute a RNA binding motif. The main differences among the gypsy elements are found in ORF3 (env-like gene); gypsyDm encodes functional env proteins, whereas gypsyDs and gypsyDv ORF3s lack some motifs essential for functionality of this protein. On the basis of these results, while gypsyDm is the first insect retrovirus described, gypsyDs and gypsyDv could constitute degenerate forms of these retroviruses. In this context, we have found some evidence that gypsyDm could have recently infected some D.subobscura strains. Comparative analyses of divergence and phylogenetic relationships of gypsy elements indicate tha...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jan 1, 1992·Genetica·A BuchetonM Simonelig
Mar 1, 1992·Trends in Genetics : TIG·M A Grandbastien
Jun 1, 1992·Molecular & General Genetics : MGG·M T McHaleR P Oliver
Dec 1, 1992·Trends in Biochemical Sciences·M W SmithR F Doolittle
May 30, 1992·The Veterinary Record·J P Sauvage
Feb 25, 1991·Nucleic Acids Research·L J Mizrokhi, A M Mazo
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·M S SpringerR J Britten
Feb 11, 1990·Nucleic Acids Research·J J MichailleA Garel
Dec 1, 1990·Molecular and Cellular Biology·H L LevinJ D Boeke
Dec 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·V S ScheinkerM B Evgen'ev
Nov 1, 1990·Molecular & General Genetics : MGG·A I KimM M Aslanian
Jul 15, 1986·European Journal of Biochemistry·S YukiK Saigo
Mar 1, 1989·The Quarterly Review of Biology·R F DoolittleM A McClure
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D R SmythJ W Sentry
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Peifer, W Bender
Dec 1, 1988·Molecular and Cellular Biology·L J HansenS B Sandmeyer
Jul 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
Mar 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J ModolellM Meselson
Jan 1, 1984·Journal of Molecular Evolution·S M Beverley, A C Wilson
Aug 1, 1994·Molecular and Cellular Biology·S TandaV G Corces
Jul 25, 1994·Molecular & General Genetics : MGG·S HagemannW Pinsker
Feb 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·A KimA Bucheton
Jan 1, 1993·Annual Review of Genetics·M G Kidwell
Feb 1, 1993·Journal of Molecular Evolution·T M Alberola, R de Frutos

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Citations

Sep 13, 2002·Insect Biochemistry and Molecular Biology·A PelissonA Bucheton
Nov 5, 2002·Molecular Phylogenetics and Evolution·M José Martínez-SebastiánRosa de Frutos
Jun 1, 2000·Molecular Biology and Evolution·C TerzianA Bucheton
Mar 4, 2000·Genome Génome / Conseil National De Recherches Canada·J CañizaresM D Moltó
Aug 16, 2008·BMC Evolutionary Biology·María Pilar García GuerreiroAntonio Fontdevila
Nov 4, 2008·BMC Evolutionary Biology·Jose V LlorensMaría J Martínez-Sebastián
Mar 21, 2008·Insect Molecular Biology·A LudwigE L S Loreto
Sep 14, 2007·Hereditas·Goran ZivanovicFrancesc Mestres
Mar 13, 2001·BMC Evolutionary Biology·G F Rohrmann, P A Karplus
Jul 26, 2000·Molecular Biology and Evolution·R P Vázquez-ManriqueR de Frutos
Jun 4, 2004·Molecular Biology and Evolution·Fabiana HerédiaVera Lúcia S Valente

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