Molecular structure of glycogen in diabetic liver

Glycoconjugate Journal
Bin DengRobert G Gilbert

Abstract

Liver glycogen (involved in maintaining blood-sugar levels) is a hyperbranched glucose polymer containing β particles (diameter ~20 nm), which can form composite α particles (diameter ~50-300 nm), and includes a small but significant amount of bound protein. Size distributions of glycogen from livers of healthy and diabetic mice were examined using size-exclusion chromatography with two separate eluents: aqueous eluent and dimethylsulfoxide (DMSO) eluent. Morphologies were examined with transmission electron microscopy. Diabetic glycogen (DG) exhibited many α particles in the mild water-based solvent, but in DMSO, which breaks H bonds, these degraded to β particles; α particles however were always present in healthy glycogen (HG). This DG fragility shows the binding of β into α particles is different in HG and DG. The diabetic α particle fragility may be involved with the uncontrolled blood-sugar release symptomatic of diabetes: small β particles degrade more easily to glucose than α particles. This has implications for diabetes management.

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Citations

Nov 2, 2015·Glycoconjugate Journal·Quinn Alexander BesfordAngus Gray-Weale
May 15, 2016·Carbohydrate Polymers·Xinle TanRobert G Gilbert
Mar 5, 2016·PloS One·Bin DengRobert G Gilbert
Oct 17, 2019·Advanced Materials·Quinn A BesfordFrank Caruso
Jan 10, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Cheng Li, Zhenxia Hu
Jan 19, 2021·IScience·Asad NawazMitchell A Sullivan
Apr 4, 2020·Carbohydrate Polymers·Liang WangDaoquan Tang
Mar 7, 2021·Carbohydrate Polymers·Mengmeng WangLiang Wang
May 12, 2018·International Journal of Biological Macromolecules·Peng ZhangRobert G Gilbert
Mar 27, 2021·Carbohydrate Polymers·Ziyi WangMitchell A Sullivan
May 18, 2021·Frontiers in Molecular Biosciences·Qing-Hua LiuLiang Wang
Jun 28, 2019·Biomacromolecules·Liang WangRobert G Gilbert

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