PMID: 8613491Nov 1, 1995Paper

Molecular structure of staphylococcus and streptococcus superantigens

Journal of Clinical Immunology
P M SchlievertY I Chi

Abstract

Staphylococcus aureus and streptococci, notably those belonging to group A, make up a large family of true exotoxins referred to as pyrogenic toxin superantigens. These toxins cause toxic shock-like syndromes and have been implicated in several allergic and autoimmune diseases. Included within this group of proteins are the staphylococcal enterotoxins, designated serotypes A, B, Cn, D, E, and G; two forms of toxic shock syndrome toxin-1 also made by Staphylococcus aureus; the group A streptococcal pyrogenic exotoxins, serotypes A, B, and C; and recently described toxins associated with groups B, C, F, and G streptococci. The nucleotide sequences of the genes for all of the toxins except those from the groups B, C, F, and G streptococcal strains have been sequenced. The sequencing studies indicate that staphylococcal enterotoxins B and C and streptococcal pyrogenic exotoxin A share highly significant sequence similarity; staphylococcal enterotoxins A, D, and E share highly significant sequence similarity; and toxic shock syndrome toxin-1 and streptococcal pyrogenic exotoxin B and C share little, if any, sequence similarity with any of the toxins. Despite the dissimilarities seen in primary amino acid sequence among some members ...Continue Reading

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Citations

May 26, 1999·Infectious Disease Clinics of North America·J BannanJ B Zabriskie
Mar 6, 1999·Current Opinion in Microbiology·D HeumannT Calandra
Jan 11, 2000·Clinical Microbiology Reviews·M M DingesP M Schlievert
Dec 19, 2000·Infection and Immunity·P M OrwinP M Schlievert
Aug 1, 2010·Toxins·Irina V PinchukVictor E Reyes
Oct 2, 2007·Dermatologic Clinics·Eleonora RuoccoMaria Antonietta Tufano
Nov 14, 2001·Dermatologic Clinics·S M Manders
May 22, 2003·Dermatologic Clinics·Mary E Garman, Ida Orengo
Nov 11, 1999·Current Opinion in Pediatrics·H S ZhuE Shapiro
Apr 6, 2002·The Journal of Biological Chemistry·Young-In ChiGregory A Bohach
Apr 20, 2005·Annals of Plastic Surgery·Ashley N Agerson, Edwin G Wilkins
Mar 3, 2019·Scientific Reports·Arundhathi VenkatasubramaniamM Javad Aman
Mar 3, 2018·Analytical Biochemistry·Hamid SedighianAbbas Ali Imani Fooladi

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