Molecular structure of the chick cerebellar kainate-binding subunit of a putative glutamate receptor.

Nature
P GregorV I Teichberg

Abstract

Kainate receptors mediate some of the excitatory transactions carried out in the central nervous system by the neurotransmitter glutamate. They are involved in neurotoxicity, possibly in neurodegenerative disorders and it has been suggested that they have a role in long-term potentiation. Kainate receptors are present both on neuronal and glial cell membranes where they regulate the gating of a voltage-independent ion channel. Nothing is known about their molecular structure. Taking advantage of the unusually high abundance of 3H-kainate binding sites in the chick cerebellum, we have isolated an oligomeric protein that displays a pharmacological profile similar to that of a kainate receptor, and have demonstrated, using the monoclonal antibody IX-50, that this protein is composed of a single polypeptide of Mr 49,000 which harbours the specific kainate recognition site. The structure of this kainate binding protein (KBP) is also of interest because of its exclusive cerebellar localization on Bergmann glial membrane in close proximity to established glutamatergic synapses. We now report the isolation of the complementary DNA containing the complete coding region of the kainate binding protein. The predicted structure of the matur...Continue Reading

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·C D BlackstoneS H Snyder
Jan 1, 1988·Glia·H SontheimerM Schachner
Jan 1, 1986·Advances in Experimental Medicine and Biology·C W Cotman, D T Monaghan
Jan 1, 1981·Annual Review of Pharmacology and Toxicology·J C Watkins, R H Evans
May 1, 1984·Analytical Biochemistry·J Meinkoth, G Wahl
May 5, 1982·Journal of Molecular Biology·J Kyte, R F Doolittle

❮ Previous
Next ❯

Citations

Jul 1, 1992·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R C Henneberry
Nov 1, 1993·The Journal of Membrane Biology·A Devillers-ThiéryJ P Changeux
Jan 1, 1990·Molecular Neurobiology·V B CockcroftG G Lunt
Jan 1, 1991·Molecular Neurobiology·G von Blankenfeld, H Kettenmann
Jul 17, 1990·European Journal of Pharmacology·D D SchoeppP L Ornstein
Feb 1, 1995·Neuropharmacology·B Bettler, C Mulle
Nov 1, 1991·Pharmacology & Therapeutics·P N Usherwood, I S Blagbrough
Dec 1, 1990·Trends in Pharmacological Sciences·E A Barnard, J M Henley
Oct 1, 1991·Trends in Pharmacological Sciences·R Dingledine
Jul 1, 1992·Trends in Pharmacological Sciences·B Sommer, P H Seeburg
Dec 1, 1993·Trends in Pharmacological Sciences·H BetzB Schmitt
Jun 1, 1994·Trends in Pharmacological Sciences·J M Henley
Apr 1, 1995·Trends in Neurosciences·Z G Wo, R E Oswald
Jan 1, 1991·Neuroscience Research·K Okamoto, M Sekiguchi
Dec 1, 1993·Neurochemistry International·V B CockcroftG G Lunt
Sep 1, 1993·Neurochemistry International·A GorodinskyV I Teichberg
Aug 1, 1992·Progress in Neurobiology·J M Barnes, J M Henley
Sep 1, 1992·Progress in Neurobiology·C F Zorumski, L L Thio
Jan 1, 1991·Neuroscience·A OrtegaV I Teichberg
Mar 1, 1993·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·M Maruyama, K Takeda
Mar 15, 1993·European Journal of Pharmacology·M E Cid, A Ortega
Jan 15, 1994·European Journal of Pharmacology·F A Taverna, D R Hampson
Jun 1, 1991·Current Opinion in Neurobiology·G P Gasic, S Heinemann
Apr 27, 1999·Brain Research. Molecular Brain Research·Z LiR E Oswald
Jun 29, 2000·Neurochemistry International·P R DoddP A Wilce
Nov 27, 2002·Progress in Neurobiology·Eiichi HinoiYukio Yoneda

❮ Previous
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