Molecular structure, vibrational spectra and DFT molecular orbital calculations (TD-DFT and NMR) of the antiproliferative drug Methotrexate

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
S AyyappanS Sebastian

Abstract

The FT-IR and FT-Raman spectral studies of the Methotrexate (MTX) were carried out. The equilibrium geometry, various bonding features and harmonic vibrational frequencies of MTX have been investigated with the help of B3LYP density functional theory (DFT) using 6-31G(d) as basis set. Detailed analysis of the vibrational spectra has been made with the aid of theoretically predicted vibrational frequencies. The vibrational analysis confirms the differently acting ring modes, steric repulsion, conjugation and back-donation. The energy and oscillator strength calculated by Time-Dependent Density Functional Theory (TD-DFT) results complement with the experimental findings. The calculated HOMO and LUMO energies show that charge transfer occur within the molecule. Good correlations between the experimental (1)H and (13)C NMR chemical shifts in DMSO solution and calculated GIAO shielding tensors were found.

References

Jan 31, 2002·Journal of Chromatography. B, Biomedical Sciences and Applications·F M Rubino

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Citations

Jun 7, 2013·Drug Delivery·Adriana De Fátima PereiraGisele Rodrigues Da Silva
Dec 30, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Zohre SadeghzadeAli Morsali
Mar 22, 2014·Environmental Technology·Patrick LipphausAndreas Nocker
Dec 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Beatriz Álvarez-GonzálezManuel Sánchez-Polo
Jun 21, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xin JiangBing Zhao
Feb 9, 2018·Environmental Science & Technology·Chao QinYanzheng Gao

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