Molecular substrates mediating lanthanide-evoked neurotransmitter release in central synapses.

Journal of Neurophysiology
ChiHye ChungEge T Kavalali

Abstract

Noncanonical secretagogues such as hypertonicity or alpha-latrotoxin have been extremely informative in studying neurotransmission. Lanthanum and lanthanides can also trigger neurotransmitter release through an unknown mechanism. Here, we studied the effect of lanthanides on neurotransmission in hippocampal cultures. Application of 2 mM La3+ caused rapid and robust neurotransmitter release within seconds. In addition, transient application of La3+ uncovered a sustained facilitation of miniature neurotransmission. The response to La3+ was detectable at 2 microM and increased in a concentration-dependent manner<or=2 mM. Rapid effect of La3+ was independent of extracellular and intracellular Ca2+ and did not require La3+ entry into cells or activation of phospholipaseCbeta. Synapses deficient in synaptobrevin-2, the major synaptic vesicle soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein in the brain, did not display any rapid release in response to La3+, whereas the slow facilitation of release detected after La3+ removal remained intact. In contrast, preincubation with intracellular Ca2+ chelators selectively attenuated the delayed release triggered by La3+. Moreover, synapses deficient in syn...Continue Reading

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Citations

Jul 23, 2013·Nature Neuroscience·Dorota StudniarczykMark Farrant
Feb 22, 2011·Current Opinion in Neurobiology·Denise M O Ramirez, Ege T Kavalali
Jul 22, 2014·Progress in Neurobiology·Stephen D MerineyCameron B Gundersen
Feb 28, 2019·Frontiers in Cellular Neuroscience·Andrei RozovFliza Valiullina-Rakhmatullina

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