Molecular substrates of social avoidance seen following prenatal ethanol exposure and its reversal by social enrichment.

Developmental Neuroscience
Frank A MiddletonSandra M Mooney

Abstract

Prenatal ethanol exposure is associated with, and is a risk factor for, developmental disorders with abnormal social behaviors, including autism spectrum disorders. We hypothesize that the specific effects of ethanol on social behavior are defined by the timing of the exposure as well as subsequent changes in brain regions such as the amygdala and ventral striatum. We recently reported that in utero ethanol exposure on gestational day 12 alters social behaviors of weanling [postnatal day (P) 28], adolescent (P42), and young adult (P75) rats. Male, but not female, offspring of the ethanol-exposed dams showed significant decreases in social investigation (sniffing of a social partner), contact behavior (grooming or crawling over/under the partner), and play fighting (following, chasing, nape attacks, or pinning) at all ages tested with maximal effects at P28 and P42. Furthermore, ethanol-exposed males and females showed evidence of social avoidance at P42 and P75. The present study sought to test whether a form of social enrichment could normalize any of the social deficits and what the molecular mechanisms of such effects might be. We found that housing rats with nonmanipulated control rats normalized the social avoidance phenot...Continue Reading

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Citations

Sep 24, 2013·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ori S CohenSandra M Mooney
Feb 13, 2014·International Journal of Epidemiology·Kristen LyallIrva Hertz-Picciotto
Aug 19, 2014·Brain Research Bulletin·Kristen A WellmannSandra M Mooney
Dec 21, 2013·Behavioural Brain Research·Elena I Varlinskaya, Sandra M Mooney
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Jun 10, 2016·Critical Reviews in Toxicology·Emma L MarczyloTimothy W Gant
Oct 17, 2017·Frontiers in Behavioral Neuroscience·Siara K RouzerMarvin R Diaz
Sep 12, 2018·Neuroscience and Biobehavioral Reviews·David De Sa NogueiraKatia Befort

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International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
Ori S CohenSandra M Mooney
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