Molecular targeted therapies in metastatic melanoma

Pharmacogenomics and Personalized Medicine
Rima ChakrabortyNneka I Comfere


The advent of personalized medicine has ushered in a new era for cancer therapy with a significant impact on the management of advanced melanoma. Molecular targeted therapies have shown promise in the management of various malignancies, including melanoma, with lower toxicity profiles and better overall survival as compared with conventional therapy. The discovery of BRAF mutations in melanoma led to the development of BRAF inhibitors for the treatment of advanced melanoma. However, growing concerns over drug resistance to molecular targeted therapies including BRAF inhibitors, have spurred efforts to elucidate additional molecular targets for the treatment of advanced melanoma. In this review, we discuss the known molecular aberrations in melanoma, current and novel targeted approaches in its treatment, and drug resistance patterns.


Sep 12, 2014·PeerJ·Trevor ArcherAnders Fredriksson
Sep 1, 2015·Journal of Proteome Research·Linsey M RaaijmakersA F Maarten Altelaar
Oct 3, 2014·Journal of Oncology·Nicole PintoAnthony C Nichols
Jul 8, 2015·Saudi Journal of Biological Sciences·Muhammad Ramzan Manwar HussainJumana Yousuf Al-Aama
Dec 3, 2014·Cancer Letters·M C F SimõesA A C C Pais
Jul 26, 2014·Cancer Treatment Reviews·David McDermottCharles M Balch
Mar 18, 2020·International Journal of Molecular Sciences·Manish AdhikariEun Ha Choi
Jun 6, 2014·International Journal of Oncology·Angela RussoMassimo Libra
Mar 17, 2018·BMJ Case Reports·Georges Al-HelouJalil Ahari

Related Concepts

BRAF protein, human
Metastatic Melanoma
Melanoma vaccine
Drug Resistance
Malignant Neoplasms
BRAF gene
Melanoma Pathway

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